SynthesisSchizophrenia bulletin2017
Developmental Differences Between Schizophrenia and Bipolar Disorder.
Synthesis in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Transdiagnostic mapping of brain structural abnormalities and network-constrained gray matter atrophy patterns across affective and psychotic disorders.Molecular psychiatry · 2026Pooled it
- Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies.Brain imaging and behavior · 2022Pooled it
- Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.Human brain mapping · 2022Pooled it
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.Biological psychiatry · 2019Pooled it
- Theory of mind variability in schizophrenia: A neurodevelopmental perspective through neurological soft signs and premorbid adjustment.Schizophrenia research. Cognition · 2025Article
- Response Monitoring Theta-Band Activities Across Emotional Contexts in Schizophrenia and Bipolar Spectrum Disorders.Biological psychiatry global open science · 2025Article
- Subjective cognition in schizophrenia and bipolar disorder: Investigation of group differences and associations with objective cognition and clinical characteristics using a novel measure of subjective cognition.Schizophrenia research. Cognition · 2025Article
- An Introduction to the Human Connectome Project for Early Psychosis.Schizophrenia bulletin · 2025Article
- Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors.Psychological medicine · 2025Article
- Early intervention in eating disorders: introducing the chronopathogram.Eating and weight disorders : EWD · 2025Review
- Sleep quality predicts future mood symptoms in adolescents with bipolar disorder.Journal of affective disorders · 2024Article
- Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers.eLife · 2024Article
- Bipolar disorders and schizophrenia: discrete disorders?Frontiers in psychiatry · 2024Review
- Brain age and cognitive functioning in first-episode bipolar disorder.Psychological medicine · 2023Article
- A comparison of neighbourhood level variation and risk factors for affective versus non-affective psychosis.Schizophrenia research · 2023Article
- Functional Alterations in Patients with Bipolar Disorder and Their Unaffected First-Degree Relatives: Insight from Genetic, Epidemiological, and Neuroimaging Data.Neuropsychiatric disease and treatment · 2023Review
- Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder.Discover mental health · 2023Article
- Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods.International journal of molecular sciences · 2022Article
- (Developmental) Motor Signs: Reconceptualizing a Potential Transdiagnostic Marker of Psychopathological Vulnerability.Schizophrenia bulletin · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ample evidence supports a neurodevelopmental origin in some cases of schizophrenia (SZ). More inconsistent information is available for bipolar disorder (BD). We herein review studies with a focus on premorbid (adjustment and functionality) and early developmental milestones that include both SZ and BD patients. A search was performed in the PubMed electronic database, retrieving 619 abstracts; 30 were ultimately included in this systematic review. Eight prospective cohorts, 15 retrospective studies, and 7 studies based on national registries. Psychomotor developmental deviations and general adjustment problems characterize the childhood of subjects later diagnosed with SZ or BD; they are more marked in those later diagnosed with SZ vs BD, earlier onset vs later onset, and psychotic vs nonpsychotic disorders. Cognitive impairment follows a linear risk trend for SZ and a U-shaped trend for BD. Social isolation and visuoperceptual/reading anomalies more frequently antecede SZ. Pervasive developmental disorders increase the risk for both SZ and BD, more so in cases with normal intelligence. The predictive risk of each isolated developmental marker is low, but a significant percentage of subjects with SZ and a minority of adults with BD showed signs of premorbid abnormalities in childhood. The great limitation is still the lack of studies comparing SZ and BD that include psychotic and nonpsychotic bipolar cases separately. There are many cases, even in childhood/adolescent SZ, where no premorbid anomalies are found, and immunological disorders or other etiologies should be searched for. At least in cases with clear neurodevelopmental markers, rare genetic variants should be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.