ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review on the effects of exercise on gut microbial diversity, taxonomic composition, and microbial metabolites: identifying research gaps and future directions.Frontiers in physiology · 2023Pooled it
- Association between physical activity and changes in intestinal microbiota composition: A systematic review.PloS one · 2021Pooled it
- Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males.Nutrients · 2022Trial
- The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome.Science advances · 2026Article
- Butyrate extends health and lifespan in mice with mitochondrial deficiency.Nature communications · 2026Article
- Mitochondrial Dysfunction and Risk Factors for Noncommunicable Diseases: From Basic Concepts to Future Prospective.Diseases (Basel, Switzerland) · 2024Review
- Physical Exercise and the Gut Microbiome: A Bidirectional Relationship Influencing Health and Performance.Nutrients · 2024Review
- The Gut Microbiome in Aging and Ovarian Cancer.Aging and cancer · 2024Article
- Article
- Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age.Aging cell · 2024Review
- Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models.Brain plasticity (Amsterdam, Netherlands) · 2024Review
- White kidney bean extract as a nutraceutical: effects on gut microbiota, alpha-amylase inhibition, and user experiences.Gut microbiome (Cambridge, England) · 2023Article
- Changes of Gut Microbiota by Natural mtDNA Variant Differences Augment Susceptibility to Metabolic Disease and Ageing.International journal of molecular sciences · 2022Article
- Aging, Gut Microbiota and Metabolic Diseases: Management through Physical Exercise and Nutritional Interventions.Nutrients · 2020Review
- Effects of high-intensity interval training on gut microbiota profiles in 12 months' old ICR mice.Journal of physiology and biochemistry · 2020Article
- Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.Microorganisms · 2020Article
- Article
- Effects of exercise frequency on the gut microbiota in elderly individuals.MicrobiologyOpen · 2020Article
- Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition.International journal of molecular sciences · 2020Article
- Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies.Frontiers in nutrition · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Mitochondrial dysfunction is prevalent in the aging gastrointestinal tract. We investigated whether mitochondrial function in aging colonic crypts and exercise influences microbial gut communities in mice. Twelve PolgAmut/mut mice were randomly divided into a sedentary and exercise group at 4 months. Seven-aged matched PolgA+/+ mice remained sedentary throughout. Stool samples were collected at 4, 7, and 11 months, and bacterial profiling was achieved through 16S rRNA sequencing profiling. Mitochondrial enzyme activity was assessed in colonic epithelial crypts at 11 months for PolgAmut/mut and PolgA+/+ mice. Sedentary and exercised PolgAmut/mut mice had significantly higher levels of mitochondrial dysfunction than PolgA+/+ mice (78%, 77%, and 1% of crypts, respectively). Bacterial profiles of sedentary PolgAmut/mut mice were significantly different from the sedentary PolgA+/+ mice, with increases in Lactobacillus and Mycoplasma, and decreases in Alistipes, Odoribacter, Anaeroplasma, Rikenella, Parabacteroides, and Allobaculum in the PolgAmut/mut mice. Exercise did not have any impact upon gut mitochondrial dysfunction; however, exercise did increase gut microbiota diversity and significantly increased bacterial genera Mucispirillum and Desulfovibrio. Mitochondrial dysfunction is associated with changes in the gut microbiota. Endurance exercise moderated some of these changes, establishing that environmental factors can influence gut microbiota, despite mitochondrial dysfunction.
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Registered trials
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