Observational studyThe Journal of antimicrobial chemotherapy2018
Staphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort study.
Observational study in The Journal of antimicrobial chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Female Sex and Mortality in Patients with Staphylococcus aureus Bacteremia: A Systematic Review and Meta-analysis.JAMA network open · 2024Pooled it
- Systematic Review and Meta-analysis of Deaths Attributable to Antimicrobial Resistance, Latin America.Emerging infectious diseases · 2023Pooled it
- Community-genotype methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Latin America: a systematic review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesPooled it
- Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026Review
- Whole-genome sequencing ofMicrobiology spectrum · 2026Article
- Clinical and laboratory predictors of mortality in Staphylococcus aureus bacteremia.Scientific reports · 2025Article
- Bloodstream infections with emphasis on Methicillin-resistant Staphylococcus aureus at the University of Gondar Comprehensive Specialized and Referral Hospital, Northwest Ethiopia.BMC infectious diseases · 2025Article
- Excess burden of antibiotic-resistant bloodstream infections: evidence from a multicentre retrospective cohort study in Chile, 2018-2022.Lancet regional health. Americas · 2024Article
- Prevalence of the cefazolin inoculum effect (CzIE) in nasal colonizing methicillin-susceptibleAntimicrobial agents and chemotherapy · 2024Article
- ST105 Lineage of MRSA: An Emerging Implication for Bloodstream Infection in the American and European Continents.Antibiotics (Basel, Switzerland) · 2024Review
- Prevalence of the Cefazolin Inoculum Effect (CzIE) in Nasal Colonizing Methicillin-SusceptiblemedRxiv : the preprint server for health sciences · 2024Article
- Molecular and Phylogenomic Analysis of a Vancomycin Intermediate Resistance USA300LV Strain in Chile.Microorganisms · 2024Article
- Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru.The American journal of tropical medicine and hygiene · 2023Article
- Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016).Microbiology spectrum · 2023Article
- Epidemiology and risk factors for mortality among methicillin-resistant Staphylococcus aureus bacteremic patients in Southern Brazil.PloS one · 2023Article
- What Is the Optimal Follow-up Length for Mortality inOpen forum infectious diseases · 2022Article
- Epidemiology, antimicrobial resistance and outcomes ofThe Lancet regional health. Western Pacific · 2022Article
- Isolation and Identification ofVeterinary sciences · 2022Article
- Epidemiology and Drug Resistance of Neonatal Bloodstream Infection Pathogens in East China Children's Medical Center From 2016 to 2020.Frontiers in microbiology · 2022Article
- Cavitary Pneumonia Due to Methicillin-Resistant Staphylococcus aureus in a Non-Immunocompromised Patient After an Endoscopy: A Case Report.The American journal of case reports · 2021Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 10 countries.
Funding
Abstract
backgroundSubstantial heterogeneity in the epidemiology and management of Staphylococcus aureus bacteraemia (SAB) occurs in Latin America. We conducted a prospective cohort study in 24 hospitals from nine Latin American countries.
objectivesTo assess the clinical impact of SAB in Latin America. PATIENTS AND
methodsWe evaluated differences in the 30 day attributable mortality among patients with SAB due to MRSA compared with MSSA involving 84 days of follow-up. Adjusted relative risks were calculated using a generalized linear model.
resultsA total of 1030 patients were included. MRSA accounted for 44.7% of cases with a heterogeneous geographical distribution. MRSA infection was associated with higher 30 day attributable mortality [25% (78 of 312) versus 13.2% (48 of 363), adjusted RR: 1.94, 95% CI: 1.38-2.73, P < 0.001] compared with MSSA in the multivariable analysis based on investigators' assessment, but not in a per-protocol analysis [13% (35 of 270) versus 8.1% (28 of 347), adjusted RR: 1.10, 95% CI: 0.75-1.60, P = 0.616] or in a sensitivity analysis using 30 day all-cause mortality [36% (132 of 367) versus 27.8% (123 of 442), adjusted RR: 1.09, 95% CI: 0.96-1.23, P = 0.179]. MRSA infection was not associated with increased length of hospital stay. Only 49% of MSSA bloodstream infections (BSI) received treatment with β-lactams, but appropriate definitive treatment was not associated with lower mortality (adjusted RR: 0.93, 95% CI: 0.70-1.23, P = 0.602).
conclusionsMRSA-BSIs in Latin America are not associated with higher 30 day mortality or longer length of stay compared with MSSA. Management of MSSA-BSIs was not optimal, but appropriate definitive therapy did not appear to influence mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.