Evidence map›Paper›PMID 29045623›Full record

ArticleChemical senses2017

The Influence of Circadian Timing on Olfactory Sensitivity.

Rachel S Herz, Eliza Van Reen, David H Barker, Cassie J Hilditch, Ashten L Bartz, Mary A Carskadon

Abstract read
In one paragraph

Article in Chemical senses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Independent effects of the human circadian system and sleep/eating cycles on caloric intake in adolescents vary by weight status.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Effects of pH on Olfactory Behaviours in Male Shore Crabs,Animals : an open access journal from MDPI · 2024
    Article
  7. Article
  8. Article
  9. Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022
    Review
  10. On the state-dependent nature of odor perception.Frontiers in neuroscience · 2022
    Review
  11. Article
  12. Article
  13. Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection.medRxiv : the preprint server for health sciences · 2020
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel S HerzDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University, USA.
Eliza Van ReenDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University, USA.
David H BarkerDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University, USA.
Cassie J HilditchE.P. Bradley Hospital Sleep Research Laboratory, USA.
Ashten L BartzE.P. Bradley Hospital Sleep Research Laboratory, USA.
Mary A CarskadonDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University, USA.

Funding

Food Choices in Overweight & Normal Weight Adolescents - Sleep & Circadian RhythmR01DK101046 · NIDDK · EMMA PENDLETON BRADLEY HOSPITAL · PI CARSKADON, MARY A · 2014 to 2018
$2.5M
NIDDK NIH HHS R01 DK101046
6 · The paper itself

Abstract

Olfactory sensitivity has traditionally been viewed as a trait that varies according to individual differences but is not expected to change with one's momentary state. Recent research has begun to challenge this position and time of day has been shown to alter detection levels. Links between obesity and the timing of food intake further raise the issue of whether odor detection may vary as a function of circadian processes. To investigate this question, 37 (21 male) adolescents (M age = 13.7 years) took part in a 28-h forced desynchrony (FD) protocol with 17.5 h awake and 10.5 h of sleep, for 7 FD cycles. Odor threshold was measured using Sniffin' Sticks 6 times for each FD cycle (total threshold tests = 42). Circadian phase was determined by intrinsic period derived from dim light melatonin onsets. Odor threshold showed a significant effect of circadian phase, with lowest threshold occurring on average slightly after the onset of melatonin production, or about 1.5○ (approximately 21:08 h). Considerable individual variability was observed, however, peak olfactory acuity never occurred between 80.5○ and 197.5○ (~02:22-10:10 h). These data are the first to show that odor threshold is differentially and consistently influenced by circadian timing, and is not a stable trait. Potential biological relevance for connections between circadian phase and olfactory sensitivity are discussed.

Indexed as

OdorantsAdolescentChildCircadian RhythmEatingFemaleHumansMaleOlfactory PerceptionSensory ThresholdsSleepWakefulnessadolescentsfood intakeforced desynchronyindividual differencesodor thresholdtrait-state

Identifiers

PMID29045623
PMCPMC5863568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.