ArticleCerebral cortex (New York, N.Y. : 1991)2017
Segregated Excitatory-Inhibitory Recurrent Subnetworks in Layer 5 of the Rat Frontal Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
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- Microcircuitry and oscillation features across model cortical regions.The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems · 2025Article
- Spiking attractor model of motor cortex explains modulation of neural and behavioral variability by prior target information.Nature communications · 2024Article
- Structural Organization of Perisomatic Inhibition in the Mouse Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex.Neuron · 2022Article
- Local connectivity and synaptic dynamics in mouse and human neocortex.Science (New York, N.Y.) · 2022Article
- State transitions through inhibitory interneurons in a cortical network model.PLoS computational biology · 2021Article
- Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex.Cell reports · 2021Article
- Model neocortical microcircuit supports beta and gamma rhythms.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2021Article
- Pyramidal cell subtype-dependent cortical oscillatory activity regulates motor learning.Communications biology · 2021Article
- Inhibitory neurons exhibit high controlling ability in the cortical microconnectome.PLoS computational biology · 2021Article
- Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits.Frontiers in neural circuits · 2021Review
- The human motor cortex microcircuit: insights for neurodegenerative disease.Nature reviews. Neuroscience · 2020Review
- Article
- The CSF-Contacting Nucleus Receives Anatomical Inputs From the Cerebral Cortex: A Combination of Retrograde Tracing and 3D Reconstruction Study in Rat.Frontiers in neuroanatomy · 2020Article
- The Synaptic Organization of Layer 6 Circuits Reveals Inhibition as a Major Output of a Neocortical Sublamina.Cell reports · 2019Article
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5 authors.
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Abstract
A prominent feature of neocortical pyramidal cells (PCs) is their numerous projections to diverse brain areas. In layer 5 (L5) of the rat frontal cortex, there are 2 major subtypes of PCs that differ in their long-range axonal projections, corticopontine (CPn) cells and crossed corticostriatal (CCS) cells. The outputs of these L5 PCs can be regulated by feedback inhibition from neighboring cortical GABAergic cells. Two major subtypes of GABAergic cells are parvalbumin (PV)-positive and somatostatin (SOM)-positive cells. PV cells have a fast-spiking (FS) firing pattern, while SOM cells have a low threshold spike (LTS) and regular spiking. In this study, we found that the 2 PC subtypes in L5 selectively make recurrent connections with LTS cells. The connection patterns correlated with the morphological and physiological diversity of LTS cells. LTS cells with high input resistance (Ri) exhibited more compact dendrites and more rebound spikes than LTS cells with low Ri, which had vertically elongated dendrites. LTS subgroups differently inhibited the PC subtypes, although FS cells made nonselective connections with both projection subtypes. These results demonstrate a novel recurrent network of inhibitory and projection-specific excitatory neurons within the neocortex.
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