ArticlePloS one2017
The psychosocial impact of leg ulcers in patients with sickle cell disease: I don't want them to know my little secret.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02156102 (Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Interventions for treating leg ulcers in people with sickle cell disease.The Cochrane database of systematic reviews · 2021Pooled it
- WHOQOL-BREF in Measuring Quality of Life Among Sickle Cell Disease Patients with Leg Ulcers.International journal of environmental research and public health · 2025Article
- Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report.Frontiers in medicine · 2023Article
- A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126.Biomolecules · 2022Article
- Communicating and understanding pain: Limitations of pain scales for patients with sickle cell disorder and other painful conditions.Journal of health psychology · 2022Article
- Prevalence of people with sickle cell disease and leg ulcers in Brazil: Socioeconomic and clinical overview.PloS one · 2022Article
- Social support networks of adults with sickle cell disease.Journal of genetic counseling · 2021Article
- Insights into the skin microbiome of sickle cell disease leg ulcers.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Article
- Severe Pain Profiles and Associated Sociodemographic and Clinical Characteristics in Individuals With Sickle Cell Disease.The Clinical journal of pain · 2021Article
- The impact of voxelotor treatment on leg ulcers in patients with sickle cell disease.American journal of hematology · 2021Article
- Topical Sevoflurane: A Novel Treatment for Chronic Pain Caused by Venous Stasis Ulcers.Anesthesiology and pain medicine · 2021Review
- Leg ulcers in sickle cell disease patients.Jornal vascular brasileiro · 2020Review
- Whole-exome sequencing indicatesExperimental biology and medicine (Maywood, N.J.) · 2019Article
- Iron Chelation with Transdermal Deferoxamine Accelerates Healing of Murine Sickle Cell Ulcers.Advances in wound care · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSickle cell disease (SCD) impacts millions of individuals worldwide and more than 100,000 people in the United States. Leg ulcers are the most common cutaneous manifestation of SCD. The health status of individuals living with chronic leg ulcers is not only influenced by clinical manifestations such as pain duration and intensity, but also by psychosocial factors. Garnering insights into the psychosocial impact can provide a more holistic view of their influence on quality of life.
methodsSemi-structured interviews were conducted with participants living with active SCD-associated leg ulcers or with a history of ulcers. Subjects were recruited from an ongoing study (INSIGHTS, Clin Trial.Gov NCT02156102) and consented to this qualitative phase of the study. Five areas were explored: leg ulcer pain, physical function, social-isolation, social relationships and religious support. Data was collected from 20 individuals during these interviews and a thematic analysis was performed and reported.
resultsTwenty participants with a mean age of 42.4 (SD ± 11.1years) were included in the study. Major themes identified included:1) pain (acute and chronic); 2) compromised physical function as demonstrated by decreased ability to walk, run, and play sports; 3) social isolation from activities either by others or self-induced as a means of avoiding certain emotions, such as embarrassment; 4) social relationships (family support and social network); 5) support and comfort through their religion or spirituality.
conclusionsSCD patients with leg ulcers expressed that they experience social isolation, intense and frequent ulcer pain, and difficulty in physical function. SCD-associated leg ulcers have been studied from a clinical approach, but the psychosocial factors investigated in this study informs how quality of life is impacted by the leg ulcers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.