Observational studyPloS one2017
Inflammatory response and oxidative stress during liver resection.
Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Pooled it
- Impact of perioperative steroid administration in patients undergoing elective liver resection: meta-analysis.BJS open · 2022Pooled it
- Assessment of the effect of perineural dexmedetomidine on oxidative stress during peritoneal dialysis catheter insertion: a randomized, controlled trial.International urology and nephrology · 2022Trial
- The effect of mannitol on oxidation-reduction potential in patients undergoing deceased donor renal transplantation-A randomized controlled trial.Acta anaesthesiologica Scandinavica · 2021Trial
- Effects of major solid cancer surgery on oxidative stress assessed by plasma xanthine oxidase and adenosine deaminase activity : a pilot study.World journal of surgical oncology · 2026Article
- Article
- Review
- Cancer therapy and cachexia.The Journal of clinical investigation · 2025Review
- Systemic Impact of Platelet Activation in Abdominal Surgery: From Oxidative and Inflammatory Pathways to Postoperative Complications.International journal of molecular sciences · 2025Review
- Article
- Is prolonged operative time associated with postoperative complications in liver surgery? An international multicentre cohort study of 5424 patients.Surgical endoscopy · 2024Article
- The Interplay between Perioperative Oxidative Stress and Hepatic Dysfunction after Human Liver Resection: A Prospective Observational Pilot Study.Antioxidants (Basel, Switzerland) · 2024Article
- Gliosis induction on locus coeruleus in a living liver donor experimental model: A brief review.Iranian journal of basic medical sciences · 2024Review
- Uncoupled redox stress: how a temporal misalignment of redox-regulated processes and circadian rhythmicity exacerbates the stressed state.Open biology · 2023Review
- Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery.Perioperative medicine (London, England) · 2023Article
- Oxidative Stress Predicts Post-Surgery Complications in Gastrointestinal Cancer Patients.Annals of surgical oncology · 2022Article
- Effect of rapid rehabilitation nursing on inflammation and liver function after laparoscopic radical resection of primary liver cancer.American journal of translational research · 2022Article
- Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.Trials · 2021Article
- Real-time observation of microcirculatory leukocytes in patients undergoing major liver resection.Scientific reports · 2021Article
- Lipidomic signatures of post-hepatectomy liver failure using porcine hepatectomy models.Annals of translational medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative complications are still a major concern after liver resection (LR). Systemic inflammation and deregulated reactive oxygen species during major abdominal surgery may impair outcome after hepatectomy.
methodsPatients undergoing LR were included in this study (n = 40). Oxidative stress (OS) was measured peri- and post-operatively as static oxidation-reduction potential markers (sORP) and antioxidant capacity ORP (cORP) by using the RedoxSYS Diagnostic system. Furthermore, Th1- and Th2-specific cytokines were assessed.
resultsWhereas there was no significant change in systemic sORP during LR and in the early postoperative course, there was a substantial decrease of cORP immediately post-surgery, and on postoperative days 1 and 3 (p<0.001). OS response was tightly regulated, as there was a significant correlation between sORP and cORP (p<0.0001; R2:0.457). An increase of OS (sORP) after LR of more than 3 mV was predictive for severe postoperative complications (53.8% vs. 12.5; p = 0.017). There was a significantly higher IL-2 (p = 0.006) and IL-5 (p = 0.001) increase during hepatectomy in patients who developed a severe morbidity.
conclusionAntioxidant capacity remained stable during LR but dropped during the post-surgical period, suggesting a consumption of antioxidants to maintain OS within healthy range. Severe postoperative complications were associated with a pronounced inflammatory response during surgery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.