Evidence map›Paper›PMID 29045352›Full record

ArticleJournal of pediatric gastroenterology and nutrition2018

Impact of Race and Ethnicity on Outcomes for Children Waitlisted for Pediatric Liver Transplantation.

Douglas B Mogul, Xun Luo, Eric K Chow, Allan B Massie, Tanjala S Purnell, Kathleen B Schwarz, Andrew M Cameron, John F P Bridges, Dorry L Segev

Abstract read
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Douglas B MogulDepartment of Pediatrics.
Xun LuoDepartment of Surgery, Johns Hopkins University School of Medicine.
Eric K ChowDepartment of Surgery, Johns Hopkins University School of Medicine.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine.
Tanjala S PurnellDepartment of Surgery, Johns Hopkins University School of Medicine.
Kathleen B SchwarzDepartment of Pediatrics.
Andrew M CameronDepartment of Surgery, Johns Hopkins University School of Medicine.
John F P BridgesDepartment of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine.

Funding

Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Improving pediatric liver transplant allocationK08HS023876 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI MOGUL, DOUGLAS · 2015 to 2019
$787k
Patient-Centered Strategies to Reduce Disparities in Access to Kidney TransplantationK01HS024600 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI PURNELL, TANJALA · 2016 to 2020
$786k
AHRQ HHS K01 HS024600AHRQ HHS K08 HS023876NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K24 DK101828
6 · The paper itself

Abstract

objectiveAfrican Americans and other minorities are known to face barriers to health care influencing their access to organ transplantation but it is not known whether these barriers exist among pediatric liver transplant waitlist candidates. We sought to determine whether outcomes on the waitlist (ie, mortality, deceased donor liver transplantation [DDLT], and living-donor liver transplantation [LDLT]) varied by race/ethnicity.

methodsNational registry data were studied to estimate the race/ethnicity-specific risk of waitlist mortality, DDLT and LDLT in children (<18 years) waitlisted between March 2002 and March 2015.

resultsThere was no evidence of racial/ethnic disparities in waitlist mortality. Compared to Caucasians, LDLT varied by race/ethnicity, with only 6.7% African Americans and 10.3% Hispanic children receiving LDLT compared with 12.4% Caucasian, 13.3% Asian, and 9.4% mix/other children. In an adjusted Cox proportional hazards model, African Americans were half as likely as Caucasians to use LDLT (hazard ratio [HR]: 0.410.550.73) but had similar use of DDLT (HR: 0.981.061.16). In a model that considered mortality, DDLT, and LDLT as competing risks, African Americans had significantly reduced incidence of LDLT (subhazard ratio [sHR]: 0.410.560.75) compared to Caucasians, but increased use of DDLT (sHR: 1.061.161.26).

conclusionsCompared to Caucasian children, African-American children are less likely to use LDLT but have higher rates of DDLT and similar survival on the waitlist. Additional research is necessary to understand the clinical and socioeconomic factors contributing to lower utilization of LDLT among African-American children awaiting transplantation.

Indexed as

AsianBlack or African AmericanHispanic or LatinoLiver TransplantationWhite PeopleAdolescentChildChild, PreschoolFemaleFollow-Up StudiesHealthcare DisparitiesHumansInfantInfant, NewbornLiving DonorsMale

Identifiers

PMID29045352
PMCPMC5825240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.