ArticlePediatric obesity2018
Relationship of circulating spexin with markers of cardiovascular disease: a pilot study in adolescents with obesity.
Article in Pediatric obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Does exercise during a ketogenic diet effectively alter appetite sensation, appetite-regulating hormones, and body composition?Experimental biology and medicine (Maywood, N.J.) · 2022Trial
- Time-dependent integrated tissue and circulating biomarker dynamics of spexin and progranulin in an experimental myocardial infarction model.Histochemistry and cell biology · 2026Article
- Unraveling the Potential Role of Spexin in Exercise-Induced Improvement of Cardiometabolic Health in Obesity and Diabetes.Current obesity reports · 2026Review
- Effect of vitamin D and location of asprosin, spexin and meteorin-like antibodies in the liver of rats with isoproterenol-induced myocardial infarction.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Association between serum spexin levels and diabetic nephropathy in patients with type 2 diabetes: a cross-sectional study.International urology and nephrology · 2025Article
- Associations Between Circulating Spexin, Obesity, and Insulin Resistance in Korean Children and Adolescents.Nutrients · 2025Article
- Involvement of central opioid and melanocortin receptors in spexin-induced hypophagia following intracerebroventricular injection in neonatal broiler chicks.BMC veterinary research · 2025Article
- Normalization of Spexin Levels in Patients with Obesity Submitted to Bariatric Surgery.Obesity surgery · 2024Article
- Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation†.Biology of reproduction · 2023Article
- Spexin level in acute myocardial infarction in the emergency department.Journal of medical biochemistry · 2023Article
- Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.Nutrients · 2023Article
- Cord Blood Levels of Spexin, Leptin, and Visfatin in Term Infants Born Small, Appropriate, and Large for Gestational Age and Their Association with Newborn Anthropometric MeasurementsJournal of clinical research in pediatric endocrinology · 2022Article
- Childhood obesity and adverse cardiometabolic risk in large for gestational age infants and potential early preventive strategies: a narrative review.Pediatric research · 2022Review
- Circulating Spexin Is Associated with Body Mass Index and Fat Mass but Not with Physical Activity and Psychological Parameters in Women across a Broad Body Weight Spectrum.Journal of clinical medicine · 2022Article
- Article
- Impact of spexin on metabolic diseases and inflammation: An updated minireview.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Serum spexin differed in newly diagnosed type 2 diabetes patients according to body mass index and increased with the improvement of metabolic status.Frontiers in endocrinology · 2022Article
- Circulating spexins in children with obesity: relation to cardiometabolic risk.European journal of clinical nutrition · 2022Article
- Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease.International journal of obesity (2005) · 2021Review
- Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin.Experimental biology and medicine (Maywood, N.J.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeSpexin, a novel peptide, has potential implications in obesity, satiety and energy homeostasis. The current study examined the relationship of spexin with various biomarkers of cardiovascular disease and endothelial function in adolescents with obesity.
methodsNineteen adolescents with obesity (age, 15.8 ± 1.7 years) were studied. Spexin, leptin and various cardiovascular disease biomarkers were measured. Endothelial function was assessed by high-resolution Doppler ultrasonography of the right brachial artery.
resultsSpexin concentration (median [interquartile range] 0.38 ng/mL [0.29-0.59 ng/mL]) was inversely correlated (r = -0.50, P = 0.03) with leptin. When participants were clustered into two groups ('high spexin and low leptin' vs. 'low spexin and high leptin'), the odds of having 'low spexin and high leptin' in participants with higher hs-CRP (≥ 3 mg/L) were 12.25 times (95 per cent CI -1 to139, P = 0.026) higher than those of participants with lower hs-CRP (<3 mg/L). Spexin levels, however, were not associated with measures of endothelial function.
conclusionsThe inverse association between spexin and leptin and the presence of higher concentrations of hs-CRP in adolescents with obesity in the setting of 'low spexin and high leptin' suggest a potential role for spexin in the regulation of satiety and certain cardiovascular risk factors in children with obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.