ArticleArthritis care & research2018
Association of Vitamin K Status Combined With Vitamin D Status and Lower-Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts.
Article in Arthritis care & research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Association of vitamin K intake with physical function, handgrip strength, and mortality among U.S. adults: NHANES 2003-2016.Nutrition research and practice · 2026Article
- Association between vitamin D deficiency, inflammatory markers, and knee osteoarthritis: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Vitamins D and K jointly protect against osteoarthritis via regulating OSCAR during osteoclastogenesis.Journal of orthopaedic translation · 2025Article
- Older Korean men with inadequate vitamin D status have lower odds of radiologic osteoarthritis.Scientific reports · 2022Article
- Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review.Drugs & aging · 2022Review
- Mind the Gap: Exploring Nutritional Health Compared With Weight Management Interests of Individuals with Osteoarthritis.Current developments in nutrition · 2022Article
- Epidemiology of osteoarthritis.Osteoarthritis and cartilage · 2022Review
- Vitamin K intake and health, consideration from the epidemiological studies.Journal of clinical biochemistry and nutrition · 2021Article
- Combined low vitamin D and K status amplifies mortality risk: a prospective study.European journal of nutrition · 2021Article
- Pain relief for osteoarthritis through combined treatment (PROACT): Protocol for a randomized controlled trial of mindfulness meditation combined with transcranial direct current stimulation in non-Hispanic black and white adults with knee osteoarthritis.Contemporary clinical trials · 2020Article
- Abortion is associated with knee osteoarthritis among older women in China: A STROBE-compliant article.Medicine · 2020Observational
- The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence.Nutrients · 2020Review
- Vitamin D in the Prevention and Treatment of Osteoarthritis: From Clinical Interventions to Cellular Evidence.Nutrients · 2019Review
- Walking balance is mediated by muscle strength and bone mineral density in postmenopausal women: an observational study.BMC musculoskeletal disorders · 2018Observational
- Association between vitamin D concentrations and knee pain in patients with osteoarthritis.PeerJ · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveVitamins K and D are important for the function of vitamin K-dependent proteins in joint tissues. It is unclear whether these nutrients are mutually important to functional outcomes related to knee osteoarthritis (OA). We evaluated the association of vitamin K and D sufficiency with lower-extremity function in the Health, Aging and Body Composition knee OA substudy (Health ABC) and conducted a replication analysis in an independent cohort, the Osteoarthritis Initiative (OAI).
methodsIn Health ABC (60% female, mean ± SD age 75 ± 3 years) baseline nutrient status was measured using circulating vitamin K and 25-hydroxyvitamin D (25[OH]D). Lower-extremity function was assessed using the Short Physical Performance Battery (SPPB) and usual 20-meter gait speed. In the OAI (58% female, mean ± SD age 61 ± 9 years), baseline nutrient intake was estimated by food frequency questionnaire. Lower-extremity function was assessed using usual 20-meter gait speed and chair stand completion time. Multivariate mixed models were used to evaluate the association of vitamin K and D status and intake with lower-extremity function over 4-5 years.
resultsHealth ABC participants with sufficient plasma vitamin K (≥1.0 nmoles/liter) and serum 25(OH)D (≥50 nmoles/liter) generally had better SPPB scores and faster usual gait speed over followup (P ≤ 0.002). In the OAI, sufficient vitamin K and vitamin D intake combined was associated with overall faster usual gait speed and chair stand completion time over followup (P ≤ 0.029).
conclusionSufficient vitamin K status combined with sufficient vitamin D status was associated with better lower-extremity function in 2 knee OA cohorts. These findings merit confirmation in vitamin K and D co-supplementation trials.
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