Evidence map›Paper›PMID 29044984›Full record

ArticleJournal of biomedical materials research. Part A2018

Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure.

Joseph B Vella, Ryan P Trombetta, Michael D Hoffman, Jason Inzana, Hani Awad, Danielle S W Benoit

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

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  15. Polycaprolactone as biomaterial for bone scaffolds: Review of literature.Journal of oral biology and craniofacial research
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph B VellaDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Ryan P TrombettaDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Michael D HoffmanDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Jason InzanaDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Hani AwadDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Danielle S W BenoitDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
University of Rochester · USUniversity of Rochester Medical Center · US

Funding

Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Tissue Engineering Strategies to Revitalize Bone AllograftsR01AR064200 · NIAMS · UNIVERSITY OF ROCHESTER · PI Danielle S. Benoit · 2013 to 2026
$4.0M
NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR064200
6 · The paper itself

Abstract

Biphasic calcium phosphate scaffolds formed via three dimensional (3D) printing technology to exhibit porosity and chemical resorbability to promote osseointegration often lack the strength and toughness required to withstand loading in bone tissue engineering applications. Herein, sintering and CaP:poly(caprolactone) (PCL) composite formation were explored to improve 3D printed scaffold strength and toughness. Hydroxyapatite and α-tricalcium phosphate (α-TCP) biphasic calcium powders were printed using phosphoric acid binder, which generated monetite and hydroxyapatite scaffolds. Upon sintering, evolution of β-TCP was observed along with an increase in flexural strength and modulus but no effect on fracture toughness was observed. Furthermore, scaffold porosity increased with sintering. Additionally, two techniques of PCL composite formation were employed: postprint precipitation and 3D print codeposition to further augment scaffold mechanical properties. While both techniques significantly improved flexural strength, flexural modulus, and fracture toughness under most conditions explored, precipitation yielded more substantial increases in these properties, which is attributed to better continuity of the PCL phase. However, precipitation also compromised surface porosity due to PCL passivation of the calcium phosphate surface, which may subsequently hinder scaffold integration and bone regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 663-672, 2018.

Indexed as

Materials TestingMechanical PhenomenaPrinting, Three-DimensionalBone and BonesCalcium PhosphatesParticle SizePolyestersPorosityTissue ScaffoldsX-Ray Diffractioncalcium phosphateCalcium PhosphatespolycaprolactonePolyesters3D printingcalcium phosphateceramic compositemechanical property refinementpoly(caprolactone)

Identifiers

PMID29044984
PMCPMC5785440
OpenAlexW2908726365

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.