Evidence map›Paper›PMID 29044882›Full record

ArticleStem cells (Dayton, Ohio)2017

Sox2 Communicates with Tregs Through CCL1 to Promote the Stemness Property of Breast Cancer Cells.

Yingxi Xu, Xiaoli Dong, Pingping Qi, Yujie Ye, Wenzhi Shen, Liang Leng, Lina Wang, Xuefei Li, Xiaohe Luo, Yanan Chen and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 105 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. New insights on anti-tumor immunity of CD8Journal of translational medicine · 2025
    Review
  10. Review
  11. Review
  12. CD4Science advances · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Breaking Immunosuppression to Enhance Cancer Stem Cell-Targeted Immunotherapy.International journal of biological sciences · 2025
    Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Yingxi XuDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Xiaoli DongDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Pingping QiDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Yujie YeDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Wenzhi ShenDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Liang LengDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Lina WangDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Xuefei LiDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Xiaohe LuoDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Yanan ChenDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Peiqing SunDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Rong XiangDepartment of Immunology, School of Medicine, Nankai University, Tianjin, People's Republic of China.
Na LiTianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai University, Tianjin, People's Republic of China.ORCID 0000-0002-0006-9687
Nankai University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNWake Forest University · US

Funding

Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor SuppressionR01CA131231 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUN, PEIQING · 2009 to 2018
$3.5M
The role of microRNA in oncogene-induced senescence and cancer developmentR01CA172115 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUN, PEIQING · 2014 to 2018
$1.8M
NCI NIH HHS R01 CA131231NCI NIH HHS R01 CA172115
6 · The paper itself

Abstract

As an important component of the tumor microenvironment, CD4

Indexed as

AnimalsBreast NeoplasmsCell Line, TumorChemokine CCL1FemaleHumansMiceNeoplastic Stem CellsSignal TransductionSOXB1 Transcription FactorsT-Lymphocytes, RegulatoryChemokine CCL1SOXB1 Transcription FactorsCancer stem cellsCCL1NF-κBSox2Tregs

Identifiers

PMID29044882
PMCPMC5958902
OpenAlexW2766988166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.