ArticleMagnetic resonance in medicine2018
Apparent diffusion coefficients of the five major metabolites measured in the human brain in vivo at 3T.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Gradient Scheme Optimization for PRESS-Localized Edited MRS Using Weighted Pathway Suppression.NMR in biomedicine · 2026Article
- High-resolution, volumetric diffusion-weighted MR spectroscopic imaging of the brain.Magnetic resonance in medicine · 2025Article
- Gradient scheme optimization for PRESS-localized edited MRS using weighted pathway suppression.bioRxiv : the preprint server for biology · 2025Article
- Article
- Single-shot diffusion trace spectroscopic imaging using radial echo planar trajectories.Magnetic resonance in medicine · 2024Article
- Single-shot diffusion trace-weighted MR spectroscopy: Comparison with unipolar and bipolar diffusion-weighted point-resolved spectroscopy.NMR in biomedicine · 2024Article
- Chronic neuropathic pain components in whiplash-associated disorders correlate with metabolite concentrations in the anterior cingulate and dorsolateral prefrontal cortex: a consensus-driven MRS re-examination.Frontiers in medicine · 2024Article
- Scyllo-inositol: Transverse relaxation time constant at 3 T and concentration changes associated with aging and alcohol use.NMR in biomedicine · 2023Article
- Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T.Magma (New York, N.Y.) · 2023Article
- Macromolecular background signal and non-Gaussian metabolite diffusion determined in human brain using ultra-high diffusion weighting.Magnetic resonance in medicine · 2022Article
- White Matter Metabolite Relaxation and Diffusion Abnormalities in First-Episode Psychosis: A Longitudinal Study.Schizophrenia bulletin · 2022Article
- In vivoMagnetic resonance in medicine · 2021Article
- Mapping complex cell morphology in the grey matter with double diffusion encoding MR: A simulation study.NeuroImage · 2021Article
- In vivo diffusion-weighted MRS using semi-LASER in the human brain at 3 T: Methodological aspects and clinical feasibility.NMR in biomedicine · 2021Article
- Changes in the intracellular microenvironment in the aging human brain.Neurobiology of aging · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeTo measure the apparent diffusion coefficients (ADC) of five main metabolites in the human brain at 3T with PRESS and STEAM, avoiding measurement biases because of cross-terms. Cross-terms arise from interactions between slice-selection and spoiler gradients in the localized spectroscopy sequence and the diffusion gradients.
methodsDiffusion-weighted spectra were acquired from the prefrontal cortex in five healthy subjects using STEAM (echo time [TE]/mixing time [TM]/pulse repetition time [TR] = 21.22/105/3000 ms, b-values = 0 and 3172 s/mm
resultsComparable trace/3 ADC values (0.14-0.18 µm
conclusionThe ADC values of the five main metabolites were successfully measured in the human brain at 3T with eliminated directional dependence. Both STEAM and PRESS can be used to probe the diffusivity of metabolites in normal brain and various pathologies on the clinical scanner with slightly higher precision achieved with STEAM for glutamate and myo-inositol. Magn Reson Med 79:2896-2901, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.