Evidence map›Paper›PMID 29044525›Full record

ArticleJournal of periodontal research2018

Susceptibility of different mouse strains to peri-implantitis.

S Hiyari, A Naghibi, R Wong, R Sadreshkevary, L Yi-Ling, S Tetradis, P M Camargo, F Q Pirih

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

S HiyariSection of Periodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
A NaghibiSection of Periodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
R WongSection of Periodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
R SadreshkevarySection of Periodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
L Yi-LingSection of Oral Pathology, School of Dentistry, University of California, Los Angeles, CA, USA.
S TetradisSection of Radiology, School of Dentistry, University of California, Los Angeles, CA, USA.
P M CamargoSection of Periodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
F Q PirihSection of Periodontics, School of Dentistry, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1670-7345
University of California, Los Angeles · US

Funding

UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramT90DE022734 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2012 to 2017
$2.3M
Mouse Genome-Wide Association Studies in LPS-Induced Bone LossR21DE023901 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIRIH, FLAVIA · 2014 to 2015
$407k
NIDCR NIH HHS R21 DE023901NIDCR NIH HHS T90 DE022734
6 · The paper itself

Abstract

BACKGROUND AND

objectivePeri-implantitis (PI) is an inflammatory condition that affects the tissues surrounding dental implants. Although the pathogenesis of PI is not fully understood, evidence suggests that the etiology is multifactorial and may include a genetic component. The aim of this study was to investigate the role of genetics in the development of peri-implantitis. MATERIAL AND

methodsFour-week-old C57BL/6J, C3H/HeJ and A/J male mice had their left maxillary molars extracted. Implants were placed in the healed extraction sockets. Upon osseointegration, ligatures were placed around the implant head for 1 or 4 weeks to induce PI. Micro-computed tomography scanning was used to measure volumetric bone loss. Histological analyses were also performed to evaluate collagen organization and the presence of neutrophils and osteoclasts.

resultsRadiographically, comparing the ligature-treated mice, C57BL/6J displayed the greatest amount of bone loss, followed by C3H/HeJ and A/J mice at 1 and 4 weeks. Histologically, at 1 week, C57BL/6J mice presented with the highest numbers of neutrophils and osteoclasts. At 4 weeks, C57BL/6J mice presented with the most active bone remodeling compared with the other two strains.

conclusionThere were significant differences in the severity of peri-implantitis among the different mouse strains, suggesting that the genetic framework can affect implant survival and success. Future work is needed to dissect the genetic contribution to the development of peri-implantitis.

Indexed as

Genetic Predisposition to DiseaseAlveolar Bone LossAnimalsBone RemodelingMice, Inbred StrainsNeutrophilsOsteoclastsPeri-Implantitisbone lossdental implantgeneticsmurine

Identifiers

PMID29044525
PMCPMC5760471
OpenAlexW2766004532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.