ArticleScientific reports2017
Crosstalk between proteins expression and lysine acetylation in response to patulin stress in Rhodotorula mucilaginosa.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Review
- Glutathione reductase plays a role in the metabolism of methylmercury degradation inMicrobiology spectrum · 2025Article
- The crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses.BMC biology · 2024Article
- Molecular Response ofJournal of fungi (Basel, Switzerland) · 2023Article
- Comprehensive review on patulin andFrontiers in plant science · 2023Review
- Article
- Cross-Talk of Protein Expression and Lysine Acetylation in Response to TMV Infection inACS omega · 2022Article
- Study on the mechanism of inhibiting patulin production by fengycin.Open life sciences · 2022Article
- Discovery and validation of novel protein markers in mucosa of portal hypertensive gastropathy.BMC gastroenterology · 2021Article
- Phytoplasma-induced Changes in the Acetylome and Succinylome ofMolecular & cellular proteomics : MCP · 2019Article
- The Response ofFrontiers in microbiology · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proteomic and lysine acetylation (Kac) changes, accompanying degradation of patulin in Rhodotorula mucilaginosa were analyzed using tandem mass tagging and N6-acetyllysine affinity enrichment followed by LC-MS/MS. Proteomic results showed that expression level of short-chain reductase protein and glutathione S-transferase involved in detoxification was significantly up-regulated. In addition, the expression levels of zinc-binding oxidoreductase and quinone oxidoreductase that are involved in antioxidant process, ABC transport and MFS transport responsible for chemical transport were activated when treated with patulin. The quantitative real time PCR (qRT-PCR) result also indicated these genes expression levels were increased when treated with patulin. Kac changes accompanying degradation of patulin in R. mucilaginosa were also observed. Totally, 130 Kac sites in 103 proteins were differentially expressed under patulin stress. The differentially up expressed modified proteins were mainly involved in tricarboxylic acid cycle and nuclear acid biosynthesis. The differentially down expressed Kac proteins were mainly classified to ribosome, oxidative phosphorylation, protein synthesis and defense to stress process. Our results suggest that patulin exposure prompt R. mucilaginosa to produce a series of actions to resist or degrade patulin, including Kac. In addition, the Kac information in R. mucilaginosa and Kac in response to patulin stress was firstly revealed.
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