ArticleNature communications2017
Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis.Genes · 2024Pooled it
- Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.PloS one · 2021Trial
- Predicted risk genotypes to cardiovascular diseases based on cholesterol ester transfer protein (CETP -rs708272) and lipoprotein lipase (LPL -rs13702) variants in worldwide populations: highest risk in populations with Native American ancestry.Molecular biology reports · 2025Article
- High-density LD-based structural variations analysis in ten Native and Mestizo Mexican populations.PloS one · 2025Article
- Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians.JCI insight · 2024Article
- Selection scan in Native Americans of Mexico identifiesHeliyon · 2024Article
- The Mexican Biobank Project promotes genetic discovery, inclusive science and local capacity building.Disease models & mechanisms · 2024Article
- Article
- The role of single nucleotide variant rs3819817 of the Histidine Ammonia-Lyase gene and 25-Hydroxyvitamin D on bone mineral density, adiposity markers, and skin pigmentation, in Mexican population.Journal of endocrinological investigation · 2023Article
- Demographic history and genetic structure in pre-Hispanic Central Mexico.Science (New York, N.Y.) · 2023Article
- A review of ancestrality and admixture in Latin America and the caribbean focusing on native American and African descendant populations.Frontiers in genetics · 2023Review
- Challenges in selecting admixture models and marker sets to infer genetic ancestry in a Brazilian admixed population.Scientific reports · 2022Article
- Somatic Mutational Landscape in Mexican Patients:International journal of molecular sciences · 2022Article
- Article
- Dietary, Cultural, and Pathogens-Related Selective Pressures Shaped Differential Adaptive Evolution among Native Mexican Populations.Molecular biology and evolution · 2022Article
- The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas.Nature communications · 2021Article
- Differences in MTHFR and LRRK2 variant's association with sporadic Parkinson's disease in Mexican Mestizos correlated to Native American ancestry.NPJ Parkinson's disease · 2021Article
- Imputation Performance in Latin American Populations: Improving Rare Variants Representation With the Inclusion of Native American Genomes.Frontiers in genetics · 2021Article
- Interaction of HLA Class II rs9272219 andFrontiers in genetics · 2021Article
- Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population.Scientific reports · 2020Article
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Authors and funding
31 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the genetic structure of Native American populations is important to clarify their diversity, demographic history, and to identify genetic factors relevant for biomedical traits. Here, we show a demographic history reconstruction from 12 Native American whole genomes belonging to six distinct ethnic groups representing the three main described genetic clusters of Mexico (Northern, Southern, and Maya). Effective population size estimates of all Native American groups remained below 2,000 individuals for up to 10,000 years ago. The proportion of missense variants predicted as damaging is higher for undescribed (~ 30%) than for previously reported variants (~ 15%). Several variants previously associated with biological traits are highly frequent in the Native American genomes. These findings suggest that the demographic and adaptive processes that occurred in these groups shaped their genetic architecture and could have implications in biological processes of the Native Americans and Mestizos of today.
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