ArticleScientific reports2017
SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Zero- to ultralow-field J-spectroscopy with a diamond magnetometer.Communications chemistry · 2026Article
- Ultra-low-field MRI: a David versus Goliath challenge in modern imaging.La Radiologia medica · 2025Review
- Zero-Field Overhauser Dynamic Nuclear Polarization.ACS omega · 2025Article
- Indirect Zero-Field Nuclear Magnetic Resonance Spectroscopy.Analytical chemistry · 2025Article
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.Chemical science · 2022Review
- Recent advances in the application of parahydrogen in catalysis and biochemistry.RSC advances · 2022Review
- In Situ SABRE Hyperpolarization with Earth's Field NMR Detection.Molecules (Basel, Switzerland) · 2019Article
- Multiple Quantum Coherences Hyperpolarized at Ultra-Low Fields.Chemphyschem : a European journal of chemical physics and physical chemistry · 2019Article
- SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange.Scientific reports · 2019Article
- Quasi-Resonance Fluorine-19 Signal Amplification by Reversible Exchange.The journal of physical chemistry letters · 2019Article
- Metabolic and Molecular Imaging with Hyperpolarised Tracers.Molecular imaging and biology · 2018Review
- Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE.The journal of physical chemistry. A · 2018Article
- Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy.Physical chemistry chemical physics : PCCP · 2018Article
- Article
- Parahydrogen-Based Hyperpolarization for Biomedicine.Angewandte Chemie (International ed. in English) · 2018Review
- SABRE hyperpolarization enables high-sensitivityThe Analyst · 2018Article
- Extending the Scope ofChemistryOpen · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultra-low-field (ULF) nuclear magnetic resonance (NMR) is a promising spectroscopy method allowing for, e.g., the simultaneous detection of multiple nuclei. To overcome the low signal-to-noise ratio that usually hampers a wider application, we present here an alternative approach to ULF NMR, which makes use of the hyperpolarizing technique signal amplification by reversible exchange (SABRE). In contrast to standard parahydrogen hyperpolarization, SABRE can continuously hyperpolarize 1 H as well as other MR-active nuclei. For simultaneous measurements of 1 H and 19 F under SABRE conditions a superconducting quantum interference device (SQUID)-based NMR detection unit was adapted. We successfully hyperpolarized fluorinated pyridine derivatives with an up to 2000-fold signal enhancement in 19 F. The detected signals may be explained by two alternative reaction mechanisms. SABRE combined with simultaneous SQUID-based broadband multinuclear detection may enable the quantitative analysis of multinuclear processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.