ArticleScientific reports2017
Priming with FGF2 stimulates human dental pulp cells to promote axonal regeneration and locomotor function recovery after spinal cord injury.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Human dental pulp stem cells for spinal cord injury.Stem cell research & therapy · 2025Review
- Effects of basic fibroblast growth factor on cartilage to bone: Time-course histological analysis ofRegenerative therapy · 2025Article
- The potential role of SCF combined with DPCs in facial nerve repair.Journal of molecular histology · 2025Article
- Therapeutic potential of melatonin-pretreated human dental pulp stem cells (hDPSCs) in an animal model of spinal cord injury.Scientific reports · 2024Article
- Review
- FGF23 alleviates neuronal apoptosis and inflammation, and promotes locomotion recovery via activation of PI3K/AKT signalling in spinal cord injury.Experimental and therapeutic medicine · 2023Article
- The Wisdom in Teeth: Neuronal Differentiation of Dental Pulp Cells.Cellular reprogramming · 2023Review
- Congenital heart disease-associated pulmonary dysplasia and its underlying mechanisms.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Review
- Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery.Tissue engineering. Part A · 2021Article
- Stem Cell-based Dental Pulp Regeneration: Insights From Signaling Pathways.Stem cell reviews and reports · 2021Review
- Zebra-Fishing for Regenerative Awakening in Mammals.Biomedicines · 2021Review
- The Regenerative Potential of bFGF in Dental Pulp Repair and Regeneration.Frontiers in pharmacology · 2021Review
- Regenerative Therapies for Spinal Cord Injury.Tissue engineering. Part B, Reviews · 2019Review
- FGF2-responsive genes in human dental pulp cells assessed using a rat spinal cord injury model.Journal of bone and mineral metabolism · 2019Article
- Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury.International journal of nanomedicine · 2018Article
- Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human dental pulp cells (DPCs), adherent cells derived from dental pulp tissues, are potential tools for cell transplantation therapy. However, little work has been done to optimize such transplantation. In this study, DPCs were treated with fibroblast growth factor-2 (FGF2) for 5-6 consecutive serial passages and were transplanted into the injury site immediately after complete transection of the rat spinal cord. FGF2 priming facilitated the DPCs to promote axonal regeneration and to improve locomotor function in the rat with spinal cord injury (SCI). Additional analyses revealed that FGF2 priming protected cultured DPCs from hydrogen-peroxide-induced cell death and increased the number of DPCs in the SCI rat spinal cord even 7 weeks after transplantation. The production of major neurotrophic factors was equivalent in FGF2-treated and untreated DPCs. These observations suggest that FGF2 priming might protect DPCs from the post-trauma microenvironment in which DPCs infiltrate and resident immune cells generate cytotoxic reactive oxygen species. Surviving DPCs could increase the availability of neurotrophic factors in the lesion site, thereby promoting axonal regeneration and locomotor function recovery.
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