ArticleNature communications2017
ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- IL-7 promotes naïve T cell motility to enable T cell scanning of dendritic cells in the LN.Cytokine · 2026Article
- T cells use focal adhesions to pull themselves through confined environments.The Journal of cell biology · 2024Article
- Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis.Nature communications · 2024Article
- Migrate3D: Software for simplified post-tracking analysis of 3D and 2D cell migration data.Research square · 2024Article
- Destabilisation of T cell-dependent humoral immunity in sepsis.Clinical science (London, England : 1979) · 2024Review
- Toxoplasma rhoptry proteins that affect encephalitis outcome.Cell death discovery · 2023Review
- Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues.eLife · 2023Article
- Article
- Correlation between speed and turning naturally arises for sparsely sampled cell movements.Physical biology · 2023Article
- Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks.F1000Research · 2023Article
- Liver Environment-Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- Effect of PD-1 Inhibitor Combined with X-Ray Irradiation on the Inflammatory Microenvironment and Lung Tissue Injury in Mice.Journal of inflammation research · 2022Article
- Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection.PLoS computational biology · 2021Article
- The spatio-temporal control of effector T cell migration.Nature reviews. Immunology · 2021Review
- Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players.International journal of molecular sciences · 2021Review
- Intravascular Crawling of Patrolling Monocytes: A Lèvy-Like Motility for Unique Search Functions?Frontiers in immunology · 2021Review
- A New Method Based on the von Mises-Fisher Distribution Shows that a Minority of Liver-Localized CD8 T Cells Display Hard-To-Detect Attraction toFrontiers in bioinformatics · 2021Article
- Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo.eLife · 2020Article
- Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes.Immunology and cell biology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Effector T cell migration through tissues can enable control of infection or mediate inflammatory damage. Nevertheless, the molecular mechanisms that regulate migration of effector T cells within the interstitial space of inflamed lungs are incompletely understood. Here, we show T cell migration in a mouse model of acute lung injury with two-photon imaging of intact lung tissue. Computational analysis indicates that T cells migrate with an intermittent mode, switching between confined and almost straight migration, guided by lung-associated vasculature. Rho-associated protein kinase (ROCK) is required for both high-speed migration and straight motion. By contrast, inhibition of Gα
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Registered trials
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