ArticleJournal of neural engineering2018
Acute in vivo testing of a conformal polymer microelectrode array for multi-region hippocampal recordings.
Article in Journal of neural engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ReBaCCA-ss: Relevance-Balanced Continuum Correlation Analysis With Smoothing and Surrogating for Quantifying Similarity Between Population Spiking Activities.Neural computation · 2026Article
- Systematic evaluation of surgical insertion of flexible neural probe arrays into deeper brain targets using length modulation methods.Journal of neural engineering · 2026Article
- A Comprehensive Research Dissemination Model for Polymer-Based Neural Interfaces.IEEE transactions on bio-medical engineering · 2026Article
- Stiffness-Tunable Neurotentacles for Minimally Invasive Implantation and Long-Term Neural Activity Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Article
- Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Bidirectional Neural Interface SoC With Adaptive IIR Stimulation Artifact Cancelers.IEEE journal of solid-state circuits · 2021Article
- Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical-hippocampal interactions.Nature neuroscience · 2021Article
- A comparison of insertion methods for surgical placement of penetrating neural interfaces.Journal of neural engineering · 2021Review
- Hybrid Multisite Silicon Neural Probe with Integrated Flexible Connector for Interchangeable Packaging.Sensors (Basel, Switzerland) · 2021Article
- Bonding methods for chip integration with Parylene devices.Journal of micromechanics and microengineering : structures, devices, and systems · 2021Article
- The Argo: a high channel count recording system for neural recording in vivo.Journal of neural engineering · 2021Article
- Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities.Micromachines · 2021Review
- Stimulation and Recording of the Hippocampus Using the Same Pt-Ir Coated Microelectrodes.Frontiers in neuroscience · 2021Article
- Fabrication of a Multilayer Implantable Cortical Microelectrode Probe to Improve Recording Potential.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2021Article
- A 512-Channel Multi-Layer Polymer-Based Neural Probe Array.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2020Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe success of a cortical prosthetic device relies upon its ability to attain resolvable spikes from many neurons in particular neural networks over long periods of time. Traditionally, lifetimes of neural recordings are greatly limited by the body's immune response against the foreign implant which causes neuronal death and glial scarring. This immune reaction is posited to be exacerbated by micromotion between the implant, which is often rigid, and the surrounding, soft brain tissue, and attenuates the quality of recordings over time. APPROACH: In an attempt to minimize the foreign body response to a penetrating neural array that records from multiple brain regions, Parylene C, a flexible, biocompatible polymer was used as the substrate material for a functional, proof-of-concept neural array with a reduced elastic modulus. This probe array was designed and fabricated to have 64 electrodes positioned to match the anatomy of the rat hippocampus and allow for simultaneous recordings between two cell-body layers of interest. A dissolvable brace was used for deep-brain penetration of the flexible array. MAIN
resultsArrays were electrochemically characterized at the benchtop, and a novel insertion technique that restricts acute insertion injury enabled accurate target placement of four, bare, flexible arrays to greater than 4 mm deep into the rat brain. Arrays were tested acutely and in vivo recordings taken intra-operatively reveal spikes in both targeted regions of the hippocampus with spike amplitudes and noise levels similar to those recorded with microwires. Histological staining of a sham array implanted for one month reveals limited astrocytic scarring and neuronal death around the implant. SIGNIFICANCE: This work represents one of the first examples of a penetrating polymer probe array that records from individual neurons in structures that lie deep within the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.