Evidence map›Paper›PMID 29043965›Full record

ArticleEmerging infectious diseases2018

Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China.

Vincent C C Cheng, Siddharth Sridhar, Shuk-Ching Wong, Sally C Y Wong, Jasper F W Chan, Cyril C Y Yip, Chi-Hung Chau, Timmy W K Au, Yu-Yan Hwang, Carol S W Yau and 3 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Japanese Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2019
    Guideline
  3. Review
  4. Article
  5. NADFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  6. A Scoping Review of Arthropod-Borne Flavivirus Infections in Solid Organ Transplant Recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Japanese Encephalitis Virus-Infected Cells.Sub-cellular biochemistry · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Comparative metavirome analysis in polytransfused patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Vincent C C Cheng
Siddharth Sridhar
Shuk-Ching Wong
Sally C Y Wong
Jasper F W Chan
Cyril C Y Yip
Chi-Hung Chau
Timmy W K Au
Yu-Yan Hwang
Carol S W Yau
Janice Y C Lo
Cheuk-Kwong Lee
Kwok-Yung Yuen
University of Hong Kong · HKGrantham Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in <1% of infected persons. Transmission of JEV via blood transfusion has not been reported. We report transmission of JEV via blood donation products from an asymptomatic viremic donor to 2 immunocompromised recipients. One recipient on high-dose immunosuppressive drugs received JEV-positive packed red blood cells after a double lung transplant; severe encephalitis and a poor clinical outcome resulted. JEV RNA was detected in serum, cerebrospinal fluid, and bronchoalveolar lavage fluid specimens. The second recipient had leukemia and received platelets after undergoing chemotherapy. This patient was asymptomatic; JEV infection was confirmed in this person by IgM seroconversion. This study illustrates that, consistent with other pathogenic flaviviruses, JEV can be transmitted via blood products. Targeted donor screening and pathogen reduction technologies could be used to prevent transfusion-transmitted JEV infection in highly JEV-endemic areas.

Indexed as

Blood TransfusionEncephalitis Virus, JapaneseDisease OutbreaksEncephalitis, JapaneseHong KongHumansImmunocompromised HostMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingPhylogenyPolymerase Chain ReactionSequence Analysis, DNAasymptomaticblood transfusionChinaencephalitisimmunocompromised hostinfection controlJapanese encephalitis viruspacked red blood cellsplateletsvector-borne infectionsviral encephalitisviruses

Identifiers

PMID29043965
PMCPMC5749455
OpenAlexW2766421244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.