ArticleImmunohematology2017
DEL phenotype.
Article in Immunohematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 15 citations in OpenAlex.
- Geographic boundary for the Asian-type DEL in south Asia.iScience · 2026Article
- Article
- Single-Tube Multiplex PCR-SSP for the Detection of RHD Variant Alleles Commonly Found in Serologically D- Phenotype Individuals in a Thai Population.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025Article
- Investigation of alloimmunization in beta-thalassemia major patients: a cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Article
- Guide to Rho(D) Immune Globulin in Women With Molecularly Defined Asian-type DEL (c.1227G>A).Annals of laboratory medicine · 2024Review
- Two Cases of Anti-D Alloimmunization in D-Negative Thai Patients as a Result of the Asian-Type DEL on Transfused Red Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Article
- Asian-type DEL (RHD*DEL1) with an allo-anti-D: A paradoxical observation in a healthy multiparous woman.Transfusion · 2023Article
- Serologically D-negative blood donors in Thailand: molecular variants and diagnostic strategy.Blood transfusion = Trasfusione del sangue · 2023Article
- DEL in China: the D antigen among serologic RhD-negative individuals.Journal of translational medicine · 2021Review
- Proceed with care: the "uncommon" serologic weak D phenotypes.Blood transfusion = Trasfusione del sangue · 2021Article
- DEL.Blood transfusion = Trasfusione del sangue · 2020Article
- Serological Detection of Rh-Del Phenotype among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar.Advances in hematology · 2020Article
- Does transfusion of Asian-type DEL red blood cells to D- recipients cause D alloimmunization?Transfusion · 2019Article
- Review
- Genomic characterization of the RH locus detects complex and novel structural variation in multi-ethnic cohorts.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- DEL phenotype in RhD-negative North Indian blood donors.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
conclusionsDEL red blood cells (RBCs) type as D- by routine serologic methods and are transfused routinely, without being identified as expressing a very weak D antigen, to D- recipients. DEL RBCs are detected only by adsorption and elution of anti-D or by molecular methods. Most DEL phenotypes have been reported in population studies conducted in East Asia, although DEL phenotypes have been detected also among Caucasian individuals. Approximately 98 percent of DEL phenotypes in East Asians are associated with the RHD*DEL1 or RHD*01EL.01 allele. The prevalence of DEL phenotypes has been reported among D- Han Chinese (30%), Japanese (28%), and Korean (17%) populations. The prevalence of DEL phenotypes is significantly lower among D- Caucasian populations (0.1%). Among the 3-5 percent of African individuals who are D-, there are no reports of the DEL phenotype. Case reports from East Asia indicate that transfusion of DEL RBCs to D- recipients has been associated with D alloimmunization. East Asian immigrants constitute 2.1 percent of the 318.9 million persons residing in the United States, and an estimated 2.8 percent are blood donors. Using these statistics, we estimate that 68-683 units of DEL RBCs from donors of East Asian ancestry are transfused as D- annually in the United States. Given the reports from East Asia of D alloimmunization attributed to transfusion of DEL RBCs, one would expect an occasional report of D alloimmunization in the United States following transfusion of DEL RBCs to a D- recipient. If such cases do occur, the most likely reason that they are not detected is the absence of active post-transfusion monitoring for formation of anti-D.
Indexed as
Identifiers
29043831PMC5676463W4293302329What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.