Evidence map›Paper›PMID 29043660›Full record

ArticleVirus genes2018

Sera of Peruvians with fever of unknown origins include viral nucleic acids from non-vertebrate hosts.

Tung Gia Phan, Juana Del Valle Mendoza, Mohammadreza Sadeghi, Eda Altan, Xutao Deng, Eric Delwart

Open access · bronzeAbstract read
In one paragraph

Article in Virus genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Oral and plasma microbiome in the context of acute febrile illness.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Identification of Viruses inMicroorganisms · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Tung Gia PhanBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Juana Del Valle MendozaSchool of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Mohammadreza SadeghiBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Eda AltanBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Xutao DengBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Eric DelwartBlood Systems Research Institute, San Francisco, CA, 94118, USA. delwarte@medicine.ucsf.edu.ORCID http://orcid.org/0000-0002-6296-4484
University of California, San Francisco · USBlood Systems Research Institute · USPeruvian University of Applied Sciences · PEUniversity of Helsinki · FI

Funding

Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
Metagenomic analysis of the human viromeR01HL083254 · NHLBI · VITALANT · PI DELWART, ERIC L · 2007 to 2010
$1.6M
National Heart, Lung, and Blood Institute R01 HL105770NHLBI NIH HHS R01 HL083254
6 · The paper itself

Abstract

Serum samples collected from 88 Peruvians with unexplained fever were analyzed for viral sequences using metagenomics. Nucleic acids of anelloviruses, pegivirus A (GBV-C), HIV, Dengue virus, and Oropouche virus were detected. We also characterized from two sera the RNA genomes of new species of partitivirus and dicistrovirus belonging to viral families known to infect fungi or arthropod, respectively. Genomic DNA of a putative fungal cellular host could be PCR amplified from the partitivirus-containing serum sample. The detection in human serum of nucleic acids from viral families not known to infect vertebrates may indicate contamination during sample collection and aliquoting or human infection by their presumed cellular host, here a fungus. The role, if any, of the non-vertebrate infecting viruses detected in serum in inducing fever is unknown.

Indexed as

DNA, ViralFever of Unknown OriginHumansMetagenomicsRNA, ViralSerumSpecimen HandlingVirus DiseasesDNA, ViralRNA, ViralDicistrovirusFeverMetagenomicsPartitivirusSera

Identifiers

PMID29043660
PMCPMC5826777
OpenAlexW2765564969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.