Evidence map›Paper›PMID 29043582›Full record

SynthesisHernia : the journal of hernias and abdominal wall surgery2017

Triclosan-coated sutures and surgical site infection in abdominal surgery: the TRISTAN review, meta-analysis and trial sequential analysis.

N A Henriksen, E B Deerenberg, L Venclauskas, R H Fortelny, J M Garcia-Alamino, M Miserez, F E Muysoms

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. The Efficacy of Antimicrobial-Coated Sutures for Preventing Incisional Surgical Site Infections in Digestive Surgery: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018
    Pooled it
  7. Trial
  8. Trial
  9. Review
  10. Article
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  12. Review
  13. Article
  14. Article
  15. Observational
  16. Review
  17. Randomised controlled trial of triclosan coatedWorld journal of orthopedics · 2019
    Review
  18. Article
  19. Surgical site infection: the "Achilles Heel" of all types of abdominal wall hernia reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 6 countries.

N A HenriksenDept. of Surgery, Zealand University Hospital, Lykkebaekvej 1, 4600, Koege, Denmark. nadiahenriksen@gmail.com.
E B DeerenbergErasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
L VenclauskasLithuanian University of Health Sciences, Kaunas, Lithuania.
R H FortelnyHernia Center, Wilhelminenspital, Vienna, Austria.
J M Garcia-AlaminoNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
M MiserezUniversity Hospitals, KU Leuven, Leuven, Belgium.
F E MuysomsMaria Middelares, Ghent, Belgium.
AZ Maria Middelares · BEErasmus MC · NLKU Leuven · BELithuanian University of Health Sciences · LTUniversity of Oxford · GBWilhelminen Hospital · ATZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSurgical site infection (SSI) is a frequent complication of abdominal surgery causing increased morbidity. Triclosan-coated sutures are recommended to reduce SSI. The aim of this systematic review and meta-analysis was to evaluate the evidence from randomized controlled trials (RCT) comparing the rate of SSI in abdominal surgery when using triclosan-coated or uncoated sutures for fascial closure.

methodsA systematic literature search was conducted using Medline, EMBASE, the Cochrane library, CINAHL, Scopus and Web of Science including publications until August 2017. The quality of the RCTs was evaluated using critical appraisal checklists from SIGN. Meta-analyses and trial sequential analysis were performed with Review Manager v5.3 and TSA software, respectively.

resultsEight RCTs on abdominal wall closure were included in the meta-analysis. In an overall comparison including both triclosan-coated Vicryl and PDS sutures for fascial closure, triclosan-coated sutures were superior in reducing the rate of SSI (OR 0.67; 0.46-0.98). When evaluating PDS sutures separately, there was no effect of triclosan-coating on the rate of SSI (OR 0.85; 0.61-1.17). Trial sequential analysis showed that the required information size (RIS) of 797 patients for triclosan-coated Vicryl sutures was almost reached with an accrued information size (AIS) of 795 patients. For triclosan-coated PDS sutures an AIS of 2707 patients was obtained, but the RIS was estimated to be 18,693 patients.

conclusionTriclosan-coated Vicryl sutures for abdominal fascial closure decrease the risk of SSI significantly and based on the trial sequential analysis further RCTs will not change that outcome. There was no effect on SSI rate with the use of triclosan-coated PDS sutures for abdominal fascial closure, and it is unknown whether additional RCTs will change that.

Indexed as

SuturesAbdomenAbdominal Wound Closure TechniquesAnti-Infective Agents, LocalHumansPolyglactin 910Surgical Wound InfectionTriclosanAnti-Infective Agents, LocalPolyglactin 910TriclosanGuidelinesHernia preventionIncisional herniaLaparotomy closure

Identifiers

PMID29043582
OpenAlexW2766811893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.