Evidence map›Paper›PMID 29043563›Full record

ArticleCerebellum (London, England)2018

Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background.

Joshua A Cuoco, Anthony W Esposito, Shannon Moriarty, Ying Tang, Sonika Seth, Alyssa R Toia, Elias B Kampton, Yevgeniy Mayr, Mussarah Khan, Mohammad B Khan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Joshua A CuocoDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Anthony W EspositoDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Shannon MoriartyDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Ying TangDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Sonika SethDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Alyssa R ToiaDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Elias B KamptonDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Yevgeniy MayrDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Mussarah KhanDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Mohammad B KhanDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Brian R MullenDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, 95064, USA.
James B AckmanDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, 95064, USA.
Faez SiddiqiDivision of Neurology and Research Institute of Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
John H WolfeDivision of Neurology and Research Institute of Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Olga V SavinovaDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA.
Raddy L RamosDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568-8000, USA. rramos02@nyit.edu.

Funding

Training Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9M
Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
Disseminated gene delivery to the CNS by human iPSC-derived neural stem cellsR01NS088667 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WOLFE, JOHN H · 2015 to 2019
$1.8M
National Institutes of Health R01-NS088667National Institutes of Health T32-NS007413NIGMS NIH HHS T32 GM008646NINDS NIH HHS R01 NS088667NINDS NIH HHS T32 NS007413
6 · The paper itself

Abstract

C57BL/6 mice exhibit spontaneous cerebellar malformations consisting of heterotopic neurons and glia in the molecular layer of the posterior vermis, indicative of neuronal migration defect during cerebellar development. Recognizing that many genetically engineered (GE) mouse lines are produced from C57BL/6 ES cells or backcrossed to this strain, we performed histological analyses and found that cerebellar heterotopia were a common feature present in the majority of GE lines on this background. Furthermore, we identify GE mouse lines that will be valuable in the study of cerebellar malformations including diverse driver, reporter, and optogenetic lines. Finally, we discuss the implications that these data have on the use of C57BL/6 mice and GE mice on this background in studies of cerebellar development or as models of disease.

Indexed as

AnimalsAnimals, NewbornCerebellar VermisFemaleHypoxanthine PhosphoribosyltransferaseLuminescent ProteinsMaleMiceMice, Inbred C57BLMice, TransgenicNervous System MalformationsReceptors, LDLReceptor, TIE-2Synaptosomal-Associated Protein 25Hypoxanthine PhosphoribosyltransferaseLuminescent ProteinsReceptors, LDLReceptor, TIE-2Synaptosomal-Associated Protein 25Tek protein, mouseC57BL/6Cerebellar developmentKnock-out miceTransgenic mice

Identifiers

PMID29043563
PMCPMC6328048

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.