ArticleBehavior genetics2018
An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register.
Article in Behavior genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed.
- Personality Genomics.Annual review of psychology · 2026Review
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.Nutrients · 2025Article
- Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations.Psychological medicine · 2025Article
- Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- A Two-Sample Mendelian Randomization Study of Neuroticism and Sleep Bruxism.Journal of dental research · 2024Article
- Childhood trajectories of internalising and externalising problems associated with a polygenic risk score for neuroticism in a UK birth cohort study.JCPP advances · 2023Article
- The genetics of neuroticism: Insights from the Maudsley rat model and human studies.Personality neuroscience · 2023Review
- Comparing Phenotypic, Genetic, and Environmental Associations between Personality and Loneliness.Journal of research in personality · 2022Article
- Inheritance of hormonal stress response and temperament in infant rhesus macaques (Macaca Mulatta): Nonadditive and sex-specific effects.Behavioral neuroscience · 2022Article
- Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees.Genes · 2021Article
- Importance of personality and coping expectancy on patient-reported hearing disability, quality of life and distress level: a study of patients referred to an audiology service.Health and quality of life outcomes · 2021Article
- Measurement and genetic architecture of lifetime depression in the Netherlands as assessed by LIDAS (Lifetime Depression Assessment Self-report).Psychological medicine · 2021Article
- Notes on Three Decades of Methodology Workshops.Behavior genetics · 2021Article
- Integration of postmortem amygdala expression profiling, GWAS, and functional cell culture assays: neuroticism-associated synaptic vesicle glycoprotein 2A (SV2A) gene is regulated by miR-133a and miR-218.Translational psychiatry · 2020Article
- An Extended Twin-Pedigree Study of Different Classes of Voluntary Exercise Behavior.Behavior genetics · 2020Article
- Genetic influences on treatment-seeking for common mental health problems in the UK biobank.Behaviour research and therapy · 2019Article
- Kids becoming less alike: A behavioral genetic analysis of developmental increases in personality variance from childhood to adolescence.Journal of personality and social psychology · 2019Article
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- Genetic and Environmental Associations Between Child Personality and Parenting.Social psychological and personality science · 2019Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores. We analyzed these data in the Mendel software package (Lange et al., Bioinformatics 29(12):1568-1570, 2013) to estimate the contributions of additive and non-additive genetic factors. In contrast to much of the earlier work based on twin data rather than on extended pedigrees, we could also estimate the contribution of shared household effects in the presence of non-additive genetic factors. The estimated broad-sense heritability of neuroticism was 47%, with almost equal contributions of additive and non-additive (dominance) genetic factors. A shared household effect explained 13% and unique environmental factors explained the remaining 40% of the variance in neuroticism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.