ArticleBreast cancer research and treatment2018
The importance of early detection of calcifications associated with breast cancer in screening.
Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 60 citations in OpenAlex.
- Retrospective Cohort Study: Extracting Coexisting Background Breast-Lesion Features from Stage I-III Invasive Breast Cancer.Cancers · 2026Article
- Magnetic Levitation Derived Metabolomic Fingerprinting Enables Exploratory Discrimination of Breast Cancer Subtypes.bioRxiv : the preprint server for biology · 2026Article
- Genistein Supplementation Affects Mineral Homeostasis in Rats with Mammary Cancer.Foods (Basel, Switzerland) · 2026Article
- Dual-modality CAD for breast cancer screening: dealing with discordant diagnosis between mammography and tomography.Frontiers in oncology · 2026Article
- Correlation Between Ultrasonographic Features and Histopathological Findings in Breast Lesions.Cureus · 2025Article
- A Novel Phantom for Standardized Microcalcification Detection Developed Using a Crystalline Growth System.Tomography (Ann Arbor, Mich.) · 2025Article
- Barriers to Early Breast Cancer Diagnosis in Sudanese Women Before the War.Breast cancer (Dove Medical Press) · 2025Article
- BI-RADS application for breast cancer screening in primary healthcare settings: assessing protocol adherence and diagnostic validity.Frontiers in oncology · 2025Article
- Interpretable Radiomic Signature for Breast Microcalcification Detection and Classification.Journal of imaging informatics in medicine · 2024Article
- Assessing the malignancy of suspicious breast microcalcifications: the role of contrast enhanced mammography.La Radiologia medica · 2024Article
- Value of mammographic microcalcifications and MRI-enhanced lesions in the evaluation of residual disease after neoadjuvant therapy for breast cancer.Quantitative imaging in medicine and surgery · 2023Article
- Detectability of category 3 or higher microcalcifications on digital mammograms: a comparative study between 5-MP color and monochrome liquid crystal display monitors.Radiological physics and technology · 2022Article
- Comprehensive quantitative malignant risk prediction of pure grouped amorphous calcifications: clinico-mammographic nomogram.Quantitative imaging in medicine and surgery · 2022Article
- Microcalcification Discrimination in Mammography Using Deep Convolutional Neural Network: Towards Rapid and Early Breast Cancer Diagnosis.Frontiers in public health · 2022Article
- Arylphosphonate-Tethered Porphyrins: Fluorescence Silencing Speaks a Metal Language in Living Enterocytes*.Chembiochem : a European journal of chemical biology · 2021Article
- Fluorescent Arylphosphonic Acids: Synergic Interactions between Bone and the Fluorescent Core.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Classification of Microcalcification Clusters in Digital Mammograms Using a Stack Generalization Based Classifier.Journal of imaging · 2019Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThe aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer.
methodsFrom a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses. Using this ground truth and the pathology reports, the sensitivity for calcification detection and the proportion of lesions with visible calcifications that developed into invasive cancer were determined.
resultsThe screening sensitivity for calcifications was 45.5%, at a specificity of 99.5%. A total of 68.4% (n = 177) of cancer-related calcifications that could have been detected earlier were associated with invasive cancer when diagnosed.
conclusionsScreening sensitivity for detection of malignant calcifications is low. Improving the detection of these early signs of cancer is important, because the majority of lesions with detectable calcifications that are not recalled immediately but detected as interval cancer or in the next screening round are invasive at the time of diagnosis.
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