Evidence map›Paper›PMID 29043085›Full record

ArticleBorderline personality disorder and emotion dysregulation2017

A pilot open series of lamotrigine in DBT-treated eating disorders characterized by significant affective dysregulation and poor impulse control.

Mary Ellen Trunko, Terry A Schwartz, Laura A Berner, Anne Cusack, Tiffany Nakamura, Ursula F Bailer, Joanna Y Chen, Walter H Kaye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Borderline personality disorder and emotion dysregulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Mary Ellen TrunkoDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Terry A SchwartzDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Laura A BernerDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Anne CusackDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Tiffany NakamuraDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Ursula F BailerDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Joanna Y ChenDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Walter H KayeDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
University of California, San Diego · US

Funding

Neural Bases of Self-regulatory Control in Bulimia NervosaF32MH108311 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BERNER, LAURA A. · 2016 to 2018
$171k
NIMH NIH HHS F32 MH108311
6 · The paper itself

Abstract

backgroundThere is little effective psychopharmacological treatment for individuals with eating disorders who struggle with pervasive, severe affective and behavioral dysregulation.

methodsThis pilot open series evaluated lamotrigine, a mood stabilizer, in the treatment of patients with eating disorders who did not respond adequately to antidepressant medications. Nine women with anorexia nervosa- or bulimia nervosa-spectrum eating disorders in partial hospital or intensive outpatient dialectical behavior therapy (DBT)-based eating disorder treatment took lamotrigine for 147 ± 79 days (mean final dose = 161.1 ± 48.6 mg/day). Participants completed standardized self-report measures of emotion dysregulation and impulsivity after lamotrigine initiation and approximately biweekly thereafter. Mood and eating disorder symptomatology were measured at lamotrigine initiation and at time of final assessment.

resultsLamotrigine and concurrent DBT were associated with large reductions in self-reported affective and behavioral dysregulation (

conclusionsAlthough our findings are limited by the confounds inherent in an open series, lamotrigine showed initial promise in reducing emotional instability and behavioral impulsivity in severely dysregulated eating-disordered patients. These preliminary results support further investigation of lamotrigine for eating disorders in rigorous controlled trials.

Indexed as

AnticonvulsantsBinge eatingEmotion dysregulationLamotriginePurging

Identifiers

PMID29043085
PMCPMC5632524
OpenAlexW2761465092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.