ArticleJournal of pain research2017
Age differences in salivary markers of inflammation in response to experimental pain: does venipuncture matter?
Article in Journal of pain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- The impact of tobacco smoking and electronic cigarette vaping on salivary biomarkers. A comparative study.The Saudi dental journal · 2022Article
- The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study.BMC neuroscience · 2021Article
- Measuring salivary markers of inflammation in health research: A review of methodological considerations and best practices.Psychoneuroendocrinology · 2021Review
- Altered levels of salivary and plasma pain related markers in temporomandibular disorders.The journal of headache and pain · 2020Article
- Profiling the Salivary microbiome of the Qatari population.Journal of translational medicine · 2020Article
- Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Does the Punishment Fit the Crime (and Immune System)? A Potential Role for the Immune System in Regulating Punishment Sensitivity.Frontiers in psychology · 2020Article
- Perceived discrimination is associated with the inflammatory response to acute laboratory stress in women at risk for cardiovascular disease.Brain, behavior, and immunity · 2018Article
- Diagnostic value of salivary CRP and IL-6 in patients undergoing anti-TNF-alpha therapy for rheumatic disease.Inflammopharmacology · 2018Article
- Saliva as a medium to detect and measure biomarkers related to pain.Scientific reports · 2018Article
- Salivary biomarkers and temporomandibular disorders: A systematic review.National journal of maxillofacial surgeryReview
- Nociception related biomolecules in the adult human saliva: A scoping review with additional quantitative focus on cortisol.Molecular painArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
An important consideration in mechanistic research using biomarkers should include the use of saliva as an alternative to blood. The use of saliva would allow the study of susceptible populations such as older adults where venipuncture may not be feasible. Although saliva has been most commonly used to measure cortisol and tumor necrosis factor-α (TNFα), there is limited evidence that other cytokines found in saliva significantly change in response to laboratory-induced pain. Therefore, the aim of the current preliminary study was to characterize the time course, duration and magnitude of changes of commonly measured pro- (interleukin [IL]-6, IL-8) and anti-inflammatory (IL-10, IL-4) cytokines in saliva samples and to test for age-related differences in separate experimental painful and non-painful control sessions. In addition, we also tested whether venipuncture results in significant cytokine alterations similar to a painful stimulus in a non-painful, non-venipuncture control session. All cytokines were significantly induced by the cold pressor task compared to a warm control session (
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