ArticleClinical, cosmetic and investigational dermatology2017
Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis.
Article in Clinical, cosmetic and investigational dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species.Nutrients · 2020Pooled it
- Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling.Nature medicine · 2026Article
- Development of Laser-Scribed Graphene Electrodes for Label-Free L-Histidine Sensing in Artificial Sweat.Biosensors · 2026Article
- Gut Microbiota Influence Host Metabolism and Immune Responses in Atopic Dermatitis: A Next-Generation Sequencing-Based Functional Profiling Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Study on the Mechanism of Anti-Atopic Dermatitis by Herba Siegesbeckiae Based on Metabolomics.Combinatorial chemistry & high throughput screening · 2026Article
- miR-182-Mediated Dysregulation of Histidine Metabolism Compromises T Cell Immunity in Sepsis.Inflammation · 2025Article
- Effect of Topical Microencapsulated Benzoyl Peroxide on the Skin Microbiome in Rosacea: A Randomized, Double-Blind, Crossover, Vehicle-Controlled Clinical Trial.The Journal of clinical and aesthetic dermatology · 2024Article
- Rare Filaggrin Variants Are Associated with Pustular Skin Diseases in Asians.International journal of molecular sciences · 2024Article
- Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis.International archives of allergy and immunology · 2024Article
- Circadian Oscillations in Skin and Their Interconnection with the Cycle of Life.International journal of molecular sciences · 2023Review
- Article
- Genome of Malassezia arunalokei and Its Distribution on Facial Skin.Microbiology spectrum · 2022Article
- HPLC method with post-column derivatization for the analysis of endogenous histidine in human saliva validated using the total-error concept.Amino acids · 2022Article
- DELOS Nanovesicles-Based Hydrogels: An Advanced Formulation for Topical Use.Pharmaceutics · 2022Article
- The Role of Diet Modification in Atopic Dermatitis: Navigating the Complexity.American journal of clinical dermatology · 2022Review
- Enantioselective Discrimination of Histidine by Means of an Achiral Cubane-Bridged Bis-Porphyrin.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression.Journal of clinical medicine · 2021Review
- Diet and Skin Barrier: The Role of Dietary Interventions on Skin Barrier Function.Dermatology practical & conceptual · 2021Review
- Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing.Polymers · 2020Article
- Influence of Histidine Administration on Ammonia and Amino Acid Metabolism: A Review.Physiological research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis (AD), also known as eczema, is one of the most common chronic skin conditions worldwide, affecting up to 16% of children and 10% of adults. It is incurable and has significant psychosocial and economic impacts on the affected individuals. AD etiology has been linked to deficiencies in the skin barrier protein, filaggrin. In mammalian skin, l-histidine is rapidly incorporated into filaggrin. Subsequent filaggrin proteolysis releases l-histidine as an important natural moisturizing factor (NMF). In vitro studies were conducted to investigate the influence of l-histidine on filaggrin processing and barrier function in human skin-equivalent models. Our further aim was to examine the effects of daily oral l-histidine supplementation on disease severity in adult AD patients. We conducted a randomized, double-blind, placebo-controlled, crossover, nutritional supplementation pilot study to explore the effects of oral l-histidine in adult AD patients (n=24). In vitro studies demonstrated that l-histidine significantly increased both filaggrin formation and skin barrier function (
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