Evidence map›Paper›PMID 29042597›Full record

ArticleScientific reports2017

Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation.

Natalia Torrealba, Mario Navarro-Marquez, Valeria Garrido, Zully Pedrozo, Diego Romero, Yuka Eura, Elisa Villalobos, Juan Carlos Roa, Mario Chiong, Koichi Kokame and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. First Glance at Myeloid Leukaemia Factor 2 in Cardiomyocytes.Journal of cardiovascular development and disease · 2025
    Article
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  5. Review
  6. Article
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  11. Article
  12. Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.International journal of molecular sciences · 2020
    Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Natalia TorrealbaAdvanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Santiago, Chile.
Mario Navarro-MarquezAdvanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Santiago, Chile.
Valeria GarridoAdvanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Santiago, Chile.
Zully PedrozoAdvanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Santiago, Chile.
Diego RomeroDepartment of Pathology, Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
Yuka EuraDepartment of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Elisa VillalobosAdvanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Santiago, Chile.
Juan Carlos RoaDepartment of Pathology, Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
Mario ChiongAdvanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Santiago, Chile.
Koichi KokameDepartment of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan. kame@ncvc.go.jp.
Sergio LavanderoAdvanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Santiago, Chile. slavander@uchile.cl.ORCID 0000-0003-4258-1483
Advanced Center for Chronic Diseases · CLNational Cerebral and Cardiovascular Center · JPPontificia Universidad Católica de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac hypertrophy is an adaptive response triggered by pathological stimuli. Regulation of the synthesis and the degradation of the Ca

Indexed as

AnimalsBiomarkersCalciumCardiomegalyDisease Models, AnimalEchocardiographyHeart Function TestsImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsMaleMembrane ProteinsMiceMice, KnockoutMyocytes, CardiacProteolysisRatsBiomarkersCalciumHerpud1 protein, mouseInositol 1,4,5-Trisphosphate ReceptorsMembrane Proteins

Identifiers

PMID29042597
PMCPMC5645377
OpenAlexW2761290071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.