ArticleScientific reports2017
Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Predicting efficacy and guiding procedure choice in non-vascularized bone grafting: a CT Radiomics and clinical predictor approach.BMC musculoskeletal disorders · 2023Trial
- [Finite element analysis of CT-based lateral classification of Japanese Investigation Committee type C1 osteonecrosis of femoral head and its prognostic value].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Impact of Preoperative Non-Collapse and Collapse Durations on Total Hip Arthroplasty Outcomes in Nontraumatic Osteonecrosis of the Femoral Head.Orthopaedic surgery · 2026Article
- Human Umbilical Cord Mesenchymal Stem Cells Protect Against Steroid-Induced Osteonecrosis of the Femoral Head Through Hippo Pathway.Biomedicines · 2026Article
- Microstructural and transcriptomic characterization of trabecular bone in idiopathic osteonecrosis of the femoral head.Scientific reports · 2025Article
- Influence of Sulcus-Deepening Trochleoplasty on Patellofemoral Cartilage Integrity in Patients With Severe Trochlear Dysplasia at Short-term to Midterm Follow-up: A Case-Control Study.Orthopaedic journal of sports medicine · 2025Article
- Senescence-driven osteonecrosis of the femoral head in the elderly-a distinct pathophysiological entity.Frontiers in medicine · 2025Article
- Application of additive manufacturing TaBw01 porous tantalum rod in ARCO stage II osteonecrosis of the femoral head.Journal of orthopaedic surgery and research · 2024Article
- Positive buttress reduction in femoral neck fractures: a literature review.Journal of orthopaedic surgery and research · 2024Review
- Clinical Characteristics, Current Treatment Options, Potential Mechanisms, Biomarkers, and Therapeutic Targets in Avascular Necrosis of Femoral Head.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Review
- A novel animal model of osteonecrosis of the femoral head based on 3D printing technology.Journal of orthopaedic surgery and research · 2023Article
- Sclerotic zone in femoral head necrosis: from pathophysiology to therapeutic implications.EFORT open reviews · 2023Review
- Mechanical properties of trabeculae and osteocyte morphology change significantly in different areas of the necrotic femoral head.Frontiers in cell and developmental biology · 2023Article
- Microrna-206 induces hypoxic necrosis of femoral head by inhibiting VEGF/PI3K/AKT signaling pathway.Frontiers in genetics · 2023Article
- Less sclerotic microarchitecture pattern with increased bone resorption in glucocorticoid-associated osteonecrosis of femoral head as compared to alcohol-associated osteonecrosis of femoral head.Frontiers in endocrinology · 2023Article
- Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis.BMC musculoskeletal disorders · 2022Article
- The Role of Structural Deterioration and Biomechanical Changes of the Necrotic Lesion in Collapse Mechanism of Osteonecrosis of the Femoral Head.Orthopaedic surgery · 2022Review
- Evolutionary course of the femoral head osteonecrosis: Histopathological - radiologic characteristics and clinical staging systems.Journal of orthopaedic translation · 2022Review
- Chondral Defects Cause Kissing Lesions in a Porcine Model.Cartilage · 2021Article
- Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism behind osteonecrosis of the femoral head (ONFH) remains unclear. The aim of this study was to explore the pathogenesis of ONFH from a biomechanical standpoint to provide a theoretical basis for improved treatments. We compared the bone structure of fractured femoral heads with that of necrotic femoral heads by Micro-CT scanning and histological evaluation. In addition, we compared the biomechanical properties of each zone in fractured femoral heads with those in necrotic femoral heads by using biomechanical tests. Compared with fractured femoral heads, bone microarchitecture and bone morphometry in necrotic zone and sclerotic zone of necrotic femoral heads have altered markedly. In addition, the biomechanical properties of the necrotic zone in femoral heads weaken markedly, while those of the sclerotic zone strengthen. We hypothesize that discordance between bone structure and function of the femoral head may be involved in the pathogenesis of ONFH and that more attention should be paid to the prevention and treatment of such discordance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.