ArticleNature communications2017
Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
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- Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOOSensors (Basel, Switzerland) · 2025Review
- Light-controlled smart materials: Supramolecular regulation and applications.Smart molecules : open access · 2024Review
- Recent Advances in Photoswitchable Fluorescent and Colorimetric Probes.Molecules (Basel, Switzerland) · 2024Review
- Amplifying dual-visible-light photoswitching in aqueous mediaChemical science · 2024Article
- A near-infrared light-activated nanoprobe for simultaneous detection of hydrogen polysulfide and sulfur dioxide in myocardial ischemia-reperfusion injury.Chemical science · 2023Article
- Breaking the photoswitch speed limit.Nature communications · 2023Article
- The Fabrication and Mechanism of a Crystalline Organic Fluorescent Probe Based on Photoinduced Electron Transfer.Molecules (Basel, Switzerland) · 2023Article
- Ligand-protected nanocluster-mediated photoswitchable fluorescent nanoprobes towards dual-color cellular imaging.Chemical science · 2023Article
- Switchable biomimetic nanochannels for on-demand SONature communications · 2023Article
- Open-Form Configurational Isomers of a Tricyanofuran-Type Metastable-State Photoacid.ACS omega · 2022Article
- Unveiling electron transfer in a supramolecular aggregate for adaptive and autonomous photochromic response.iScience · 2021Article
- Highly Efficient Förster Resonance Energy Transfer Modulations of Dual-AIEgens between a Tetraphenylethylene Donor and a Merocyanine Acceptor in Photo-Switchable [2]Rotaxanes and Reversible Photo-Patterning Applications.ACS applied materials & interfaces · 2020Article
- Multi-Stimuli Responsive FRET Processes of Bifluorophoric AIEgens in an Amphiphilic Copolymer and Its Application to Cyanide Detection in Aqueous Media.ACS applied materials & interfaces · 2020Article
- Unveiling how intramolecular stacking modes of covalently linked dimers dictate photoswitching properties.Nature communications · 2019Article
- Dual-color fluorescent nanoparticles showing perfect color-specific photoswitching for bioimaging and super-resolution microscopy.Nature communications · 2019Article
- Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor.Beilstein journal of organic chemistry · 2019Article
- Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging.Frontiers in chemistry · 2019Article
- Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography.Nature communications · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of powerful fluorescence imaging probes and techniques sets the basis for the spatiotemporal tracking of cells at different physiological and pathological stages. While current imaging approaches rely on passive probe-analyte interactions, here we develop photochromic fluorescent glycoprobes capable of remote light-controlled intracellular target recognition. Conjugation between a fluorophore and spiropyran produces the photochromic probe, which is subsequently equipped with a glycoligand "antenna" to actively localize a target cell expressing a selective receptor. We demonstrate that the amphiphilic glycoprobes that form micelles in water can selectively enter the target cell to operate photochromic cycling as controlled by alternate UV/Vis irradiations. We further show that remote light conversion of the photochromic probe from one isomeric state to the other activates its reactivity toward a target intracellular analyte, producing locked fluorescence that is no longer photoisomerizable. We envision that this research may spur the use of photochromism for the development of bioimaging probes.Fluorescence sensing in biological environments is prone to background signal interference. Here the authors design a photochromic fluorescent glycoprobe for light-controlled photo-switchable cell imaging and photo-activated target recognition, resulting in an increased sensing precision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.