ArticleNature communications2017
Mass spectrometry sequencing of long digital polymers facilitated by programmed inter-byte fragmentation.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Finding REMO: a sequencing method for recognition-encoded melamine oligomers.Chemical science · 2026Article
- Highly robust molecular information carriers for traceability of plastic materials.Nature communications · 2026Article
- Reference-Free Quantitative Mass Spectrometry Enables Sequencing of Resist Copolymers and Reveals Sequence-Dependent Deprotection Sensitivity.Macromolecules · 2026Article
- Reticular Frameworks for Advanced Polymer Materials.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Acceleration, simplification and potential parallelization of digital polymers sequencing by coupling tandem mass spectrometry with ion mobility.Nature communications · 2025Article
- Article
- Reconstruction of Multiple Strings of Constant Weight from Prefix-Suffix Compositions.Entropy (Basel, Switzerland) · 2025Article
- Complex Sequence-Defined Heteropolymers Enable Controlled Film Growth in Layer-By-Layer Assembly.Macromolecular rapid communications · 2024Article
- Article
- Influence Analysis of Modified Polymers as a Marking Agent for Material Tracing during Cyclic Injection Molding.Materials (Basel, Switzerland) · 2023Article
- Investigations for Material Tracing in Selective Laser Sintering: Part ΙΙ: Validation of Modified Polymers as Marking Agents.Materials (Basel, Switzerland) · 2023Article
- Investigations for Material Tracing in Selective Laser Sintering: Part Ι: Methodical Selection of a Suitable Marking Agent.Materials (Basel, Switzerland) · 2023Article
- Molecular Encryption and Steganography Using Mixtures of Simultaneously Sequenced, Sequence-Defined Oligourethanes.ACS central science · 2022Article
- Efficient molecular encoding in multifunctional self-immolative urethanes.Cell reports. Physical science · 2021Article
- Applications of Discrete Synthetic Macromolecules in Life and Materials Science: Recent and Future Trends.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Aerolysin nanopores decode digital information stored in tailored macromolecular analytes.Science advances · 2020Article
- Dual sequence definition increases the data storage capacity of sequence-defined macromolecules.Communications chemistry · 2020Article
- Encoding Information into Polyethylene Glycol Using an Alcohol-Isocyanate "Click" Reaction.International journal of molecular sciences · 2020Article
- High-density information storage in an absolutely defined aperiodic sequence of monodisperse copolyester.Nature communications · 2020Article
- Photo-editable macromolecular information.Nature communications · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the context of data storage miniaturization, it was recently shown that digital information can be stored in the monomer sequences of non-natural macromolecules. However, the sequencing of such digital polymers is currently limited to short chains. Here, we report that intact multi-byte digital polymers can be sequenced in a moderate resolution mass spectrometer and that full sequence coverage can be attained without requiring pre-analysis digestion or the help of sequence databases. In order to do so, the polymers are designed to undergo controlled fragmentations in collision-induced dissociation conditions. Each byte of the sequence is labeled by an identification tag and a weak alkoxyamine group is placed between 2 bytes. As a consequence of this design, the NO-C bonds break first upon collisional activation, thus leading to a pattern of mass tag-shifted intact bytes. Afterwards, each byte is individually sequenced in pseudo-MS
Identifiers
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Registered trials
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