Evidence map›Paper›PMID 29042551›Full record

ArticleNature communications2017

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.

Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O'Dushlaine, Ross Swofford, Daniel Howrigan, Diane P Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grünblatt and 22 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  14. Observational
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  16. Genetics of obsessive-compulsive disorder.Psychological medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 13 institutions in 6 countries.

Hyun Ji NohBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. noh@broadinstitute.org.ORCID http://orcid.org/0000-0002-6634-0599
Ruqi TangBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Jason FlannickBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Colm O'DushlaineBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Ross SwoffordBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Daniel HowriganBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Diane P GenereuxBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Jeremy JohnsonBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Gerard van GrootheestGGZ inGeest and Department of Psychiatry, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4350-6661
Edna GrünblattDepartment of Child & Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Neumünsterallee 9, Zurich, 8032, Switzerland.ORCID http://orcid.org/0000-0001-8505-7265
Erik AnderssonDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.
Diana R DjurfeldtDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.
Paresh D PatelDepartment of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA.
Michele KoltookianBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
Christina M HultmanDepartment of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
Michele T PatoDepartment of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA.
Carlos N PatoDepartment of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA.
Steven A RasmussenDepartment of Psychiatry & Human Behavior, Brown Medical School, 345 Blackstone Boulevard, Box G-BH, Providence, RI, 02906, USA.
Michael A JenikeDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA, 02215, USA.
Gregory L HannaDepartment of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-0742-6990
S Evelyn StewartBC Mental Health & Addictions Research Institute, UBC, 2255 Wesbrook Mall, Vancouver, BC, Canada, V6T 2A1.
James A KnowlesDepartment of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA.ORCID http://orcid.org/0000-0002-3307-5741
Stephan RuhrmannDepartment of Psychiatry & Psychotherapy, University of Cologne, Kerpener Street 62, Cologne, 50937, Germany.
Hans-Jörgen GrabeDepartment of Psychiatry & Psychotherapy, University of Medicine Greifswald, Fleischmannstrasse 8, Greifswald, 17475, Germany.
Michael WagnerDepartment of Psychiatry & Psychotherapy, University of Bonn, Regina-Pacis-Weg 3, Bonn, 53113, Germany.
Christian RückDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.
Carol A MathewsDepartment of Psychiatry & Genetics Institute, University of Florida, 1149 Newell Drive, Gainesville, FL, 32610, USA.
Susanne WalitzaDepartment of Child & Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Neumünsterallee 9, Zurich, 8032, Switzerland.
Daniëlle C CathDepartment of Clinical & Health Psychology, Utrecht University, Heidelberglaan 1, Utrecht, CS, 3584, The Netherlands.
Guoping FengDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA, 02139, USA.
Elinor K KarlssonBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. elinor@broadinstitute.org.ORCID http://orcid.org/0000-0002-4343-3776
Kerstin Lindblad-TohBroad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. kersli@broadinstitute.org.
Broad Institute · USKarolinska Institutet · SEStockholm County Council · SEUniversity of Michigan · USUniversity of Zurich · CHGGZ inGeest · NLHarvard University · USProvidence College · USUniversitätsmedizin Greifswald · DEUniversity of Bonn · DEUniversity of Cologne · DEUniversity of Florida · USUtrecht University · NL

Funding

2/3 Brain Function and Genetics in Pediatric Obsessive-Compulsive BehaviorsR01MH085321 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANNA, GREGORY L. · 2009 to 2019
$2.9M
Action Monitoring and Genomic Variants in Pediatric Obsessive-Compulsive BehaviorR01MH101493 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARNOLD, PAUL DANIEL, GEHRING, WILLIAM J · 2013 to 2016
$2.3M
Behavioral Genetics and Neuropsychiatric Disorders in a Natural Model SystemR21MH109938 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KARLSSON, ELINOR · 2016 to 2017
$461k
European Research CouncilNIMH NIH HHS R01 MH085321NIMH NIH HHS R01 MH101493NIMH NIH HHS R21 MH109938
6 · The paper itself

Abstract

Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method that prioritizes likely functional variants, we compared 592 cases to 560 controls and found four strongly associated genes, validated in a larger cohort. NRXN1 and HTR2A are enriched for coding variants altering postsynaptic protein-binding domains. CTTNBP2 (synapse maintenance) and REEP3 (vesicle trafficking) are enriched for regulatory variants, of which at least six (35%) alter transcription factor-DNA binding in neuroblastoma cells. NRXN1 achieves genome-wide significance (p = 6.37 × 10

Indexed as

Calcium-Binding ProteinsCarrier ProteinsCell Adhesion Molecules, NeuronalCohort StudiesHumansMembrane Transport ProteinsNerve Tissue ProteinsNeural Cell Adhesion MoleculesObsessive-Compulsive DisorderPolymorphism, Single NucleotideProteinsSignal TransductionSynapsesCalcium-Binding ProteinsCarrier ProteinsCell Adhesion Molecules, NeuronalCTTNBP2 protein, humanMembrane Transport ProteinsNerve Tissue ProteinsNeural Cell Adhesion MoleculesNRXN1 protein, humanProteinsREEP3 protein, human

Identifiers

PMID29042551
PMCPMC5645406
OpenAlexW2759075920

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.