ArticleNature communications2017
Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 99 citations in OpenAlex.
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- A quadriphasic mechanical model of the human dermis.Biomechanics and modeling in mechanobiology · 2024Article
- Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of Aging Skin.Journal of biomechanical engineering · 2024Article
- Cracks in tensile-contracting and tensile-dilating poroelastic materials.International journal of solids and structures · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Fracture toughness of fibrin gels as a function of protein volume fraction: Mechanical origins.Acta biomaterialia · 2023Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Rheology of fibrous gels under compression.Extreme Mechanics Letters · 2022Article
- Risky interpretations across the length scales: continuum vs. discrete models for soft tissue mechanobiology.Biomechanics and modeling in mechanobiology · 2022Article
- Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading.Journal of biomechanical engineering · 2022Article
- Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: anRoyal Society open science · 2022Article
- Synthetic hydrogels as blood clot mimicking wound healing materials.Progress in biomedical engineering (Bristol, England) · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the mechanisms of deformation of biological materials is important for improved diagnosis and therapy, fundamental investigations in mechanobiology, and applications in tissue engineering. Here we demonstrate the essential role of interstitial fluid mobility in determining the mechanical properties of soft tissues. Opposite to the behavior expected for a poroelastic material, the tissue volume of different collagenous membranes is observed to strongly decrease with tensile loading. Inverse poroelasticity governs monotonic and cyclic responses of soft biomembranes, and induces chemo-mechanical coupling, such that tensile forces are modulated by the chemical potential of the interstitial fluid. Correspondingly, the osmotic pressure varies with mechanical loads, thus providing an effective mechanism for mechanotransduction. Water mobility determines the tissue's ability to adapt to deformation through compaction and dilation of the collagen fiber network. In the near field of defects this mechanism activates the reversible formation of reinforcing collagen structures which effectively avoid propagation of cracks.How soft tissues respond to mechanical load is essential to their biological function. Here, the authors discover that - contrary to predictions of poroelasticity - fluid mobility in collagenous tissues induces drastic volume decrease with tensile loading and pronounced chemo-mechanical coupling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.