Evidence map›Paper›PMID 29042489›Full record

ArticleClinical science (London, England : 1979)2017

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia.

Anna E Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M Alexander

Abstract read
In one paragraph

Article in Clinical science (London, England : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. ETAmerican journal of physiology. Heart and circulatory physiology · 2021
    Trial
  3. Article
  4. Article
  5. Article
  6. Methods for analyzing acetylcholine-induced vasodilation in human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Reduced ATHypertension (Dallas, Tex. : 1979) · 2025
    Article
  13. Therapeutic potential of extracellular vesicles for treating human pregnancy disorders.Extracellular vesicles and circulating nucleic acids · 2025
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anna E StanhewiczDepartment of Kinesiology, The Pennsylvania State University, University Park, PA 16802, U.S.A. axs1056@psu.edu.
Sandeep JanduDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A.
Lakshmi SanthanamDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A.
Lacy M AlexanderDepartment of Kinesiology, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Johns Hopkins University · USPennsylvania State University · US

Funding

Essential Hypertension & Human Skin Blood FlowR01HL093238 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI ALEXANDER, LACY M. · 2009 to 2018
$4.3M
Microvascular Mechanisms Underlying Persistent Vessel Dysfunction Following PreeclampsiaF32HL129677 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI STANHEWICZ, ANNA · 2015 to 2017
$138k
NHLBI NIH HHS F32 HL129677NHLBI NIH HHS R01 HL093238
6 · The paper itself

Abstract

Microvascular dysfunction originating during a preeclamptic pregnancy persists postpartum and probably contributes to increased CVD risk in these women. One putative mechanism contributing to this dysfunction is increased vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ET

Indexed as

AcetylcholineAdultBiopsyEndothelin-1Endothelium, VascularFemaleGalvanic Skin ResponseHumansMicrodialysisMicrovesselsNitric OxideNorepinephrinePre-EclampsiaPregnancyReceptor, Endothelin AReceptor, Endothelin BAcetylcholineEndothelin-1Nitric OxideNorepinephrineReceptor, Endothelin AReceptor, Endothelin Bendothelial dysfunctionendothelin-1microvascularpreeclampsia

Identifiers

PMID29042489
PMCPMC5922254
OpenAlexW2767083709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.