Evidence map›Paper›PMID 29042488›Full record

ArticleClinical science (London, England : 1979)2017

Natural killer cells mediate pathophysiology in response to reduced uterine perfusion pressure.

Jamil Elfarra, Lorena M Amaral, Maggie McCalmon, Jeremy D Scott, Mark W Cunningham, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C Cornelius

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical science (London, England : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Immunology of Hypertension: Pathophysiological and Therapeutic Aspects.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Progesterone-induced blocking factor blockade causes hypertension in pregnant rats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Update on Immune Mechanisms in Hypertension.American journal of hypertension · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jamil ElfarraDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Lorena M AmaralDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Maggie McCalmonDepartment of Emergency Medicine, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Jeremy D ScottDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Mark W CunninghamDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Ashley GnamDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Tarek IbrahimDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Babbette LaMarcaDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
Denise C CorneliusDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A. dcornelius@umc.edu.
University of Mississippi Medical Center · US

Funding

Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
The Kidney, Hypertension, Pregnancy and InflammationR01HD067541 · NICHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI LAMARCA, BABBETTE · 2011 to 2020
$3.1M
Hypertension and InflammationR00HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2017 to 2019
$747k
Hypertension and InflammationK99HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2016 to 2016
$136k
NHLBI NIH HHS K99 HL130456NHLBI NIH HHS R00 HL130456NHLBI NIH HHS T32 HL105324NICHD NIH HHS R01 HD067541
6 · The paper itself

Abstract

Preeclampsia is associated with hypertension, small-for-gestational-age babies, and increased cytolytic natural killer (NK) cells. The specific role of cytolytic NK cells in the pathophysiology of preeclampsia has not been clearly defined. We hypothesized that

Indexed as

Blood PressurePerfusionAnimalsCytotoxicity, ImmunologicFemaleFetal Growth RetardationFetusHypertensionInflammation MediatorsInterferon-gammaIschemiaKiller Cells, NaturalPlacentaPregnancyRats, Sprague-DawleyTumor Necrosis Factor-alphaInflammation MediatorsInterferon-gammaTumor Necrosis Factor-alphaHypertensionInflammationIntrauterine growth restrictionNatural Killer CellsPreeclampsiaPregnancy

Identifiers

PMID29042488
PMCPMC5864106
OpenAlexW2767038304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.