Evidence map›Paper›PMID 29042456›Full record

Trial reportJournal of the American Society of Nephrology : JASN2018

Effects of Two Immunosuppressive Treatment Protocols for IgA Nephropathy.

Thomas Rauen, Christina Fitzner, Frank Eitner, Claudia Sommerer, Martin Zeier, Britta Otte, Ulf Panzer, Harm Peters, Urs Benck, Peter R Mertens and 7 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 10 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 10 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
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  5. Immunosuppressive therapy for IgA nephropathy in children.The Cochrane database of systematic reviews · 2024
    Pooled it
  6. Pooled it
  7. Non-immunosuppressive treatment for IgA nephropathy.The Cochrane database of systematic reviews · 2024
    Pooled it
  8. Pooled it
  9. Immunosuppressive agents for treating IgA nephropathy.The Cochrane database of systematic reviews · 2020
    Pooled it
  10. Pooled it
  11. Trial
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 1 country.

Thomas RauenDivision of Nephrology and Clinical Immunology and.
Christina FitznerDepartment of Medical Statistics, RWTH Aachen University, Aachen, Germany.
Frank EitnerDivision of Nephrology and Clinical Immunology and.
Claudia SommererDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Martin ZeierDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Britta OtteInternal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany.
Ulf PanzerMedical Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Harm PetersDepartment of Nephrology and Intensive Care and.
Urs BenckDepartment of Medicine V, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Peter R MertensDepartment of Nephrology and Hypertension, Diabetes and Endocrinology, Otto von Guericke University, Magdeburg, Germany.
Uwe KuhlmannMedical Clinic III, Central Hospital Bremen, Bremen, Germany.
Oliver WitzkeDepartments of Infectious Diseases and.
Oliver GrossClinic for Nephrology and Rheumatology, University Medical Center Goettingen, Goettingen, Germany.
Volker VielhauerNephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximilians Universität, Munich, Germany; and.
Johannes F E MannDepartment of Nephrology, Hypertension and Rheumatology, Munich General Hospitals, Munich, Germany.
Ralf-Dieter HilgersDepartment of Medical Statistics, RWTH Aachen University, Aachen, Germany.
Jürgen FloegeDivision of Nephrology and Clinical Immunology and juergen.floege@rwth-aachen.de.
Heidelberg University · DERWTH Aachen University · DEBayer (Germany) · DECharité - Universitätsmedizin Berlin · DELMU Klinikum · DEMünchen Klinik · DEOtto-von-Guericke University Magdeburg · DEUniversität Hamburg · DEUniversity Hospital Heidelberg · DEUniversity Hospital Münster · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of immunosuppression in IgA nephropathy (IgAN) is controversial. In the Supportive Versus Immunosuppressive Therapy for the Treatment of Progressive IgA Nephropathy (STOP-IgAN) Trial, 162 patients with IgAN and proteinuria >0.75 g/d after 6 months of optimized supportive care were randomized into two groups: continued supportive care or additional immunosuppression (GFR≥60 ml/min per 1.73 m

Indexed as

Adrenal Cortex HormonesAdultAnti-Inflammatory AgentsAzathioprineCyclophosphamideDrug Therapy, CombinationFemaleGlomerular Filtration RateGlomerulonephritis, IGAGlucose IntoleranceHumansImmunosuppression TherapyImmunosuppressive AgentsInfectionsIntention to Treat AnalysisMaleAdrenal Cortex HormonesAnti-Inflammatory AgentsAzathioprineCyclophosphamideImmunosuppressive AgentsPrednisoloneglomerular diseaseglomerulonephritisIgA nephropathyimmunosuppression

Identifiers

PMID29042456
PMCPMC5748925
OpenAlexW2765660894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.