ArticleJournal of the American Society of Nephrology : JASN2018
Complement-Activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment.
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Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis.PLoS medicine · 2018Pooled it
- Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization therapy: A randomized trial.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Trial
- Understanding the role of non-HLA antibodies in kidney transplantation: a literature review.Frontiers in immunology · 2026Review
- Evolving Therapeutic Approaches for Treatment of Antibody-Mediated Rejection in Renal Allograft Recipients.Results and problems in cell differentiation · 2026Review
- Desensitization in HLA-incompatible kidney transplant recipients: current strategies and emerging perspectives.Clinical kidney journal · 2025Review
- Contribution of long-lived plasma cells to antibody-mediated allograft rejection.Clinical transplantation and research · 2024Review
- Some Human Anti-Glycan Antibodies Lack the Ability to Activate the Complement System.Antibodies (Basel, Switzerland) · 2024Article
- "Eculizumab First" in the Management of Posttransplant Thrombotic Microangiopathy.Kidney international reports · 2024Article
- Translating B cell immunology to the treatment of antibody-mediated allograft rejection.Nature reviews. Nephrology · 2024Review
- The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- European Consensus on the Management of Sensitized Kidney Transplant Recipients: A Delphi Study.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Antibody-Mediated Rejection in Lung Transplantation: Diagnosis and Therapeutic Armamentarium in a 21st Century Perspective.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- De Novo Donor-Specific Antibodies after Heart Transplantation: A Comprehensive Guide for Clinicians.Journal of clinical medicine · 2023Review
- Clinical Outcome of Kidney Transplant Recipients with C1q-Binding De Novo Donor Specific Antibodies: A Single-Center Experience.Journal of clinical medicine · 2023Article
- Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation.Journal of clinical medicine · 2023Article
- Identification of driver genes in lupus nephritis based on comprehensive bioinformatics and machine learning.Frontiers in immunology · 2023Article
- Antibody-mediated rejection: prevention, monitoring and treatment dilemmas.Current opinion in organ transplantation · 2022Review
- Adaptive immune cell responses as therapeutic targets in antibody-mediated organ rejection.Trends in molecular medicine · 2022Review
- Protection of transplants against antibody-mediated injuries: from xenotransplantation to allogeneic transplantation, mechanisms and therapeutic insights.Frontiers in immunology · 2022Review
- The Role of Fc Gamma Receptors in Antibody-Mediated Rejection of Kidney Transplants.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
Corrections and comments
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Authors and funding
25 authors at 16 institutions in 6 countries.
Carmen LefaucheurParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France; carmen.lefaucheur@wanadoo.fr alexandreloupy@gmail.com.ORCID 0000-0002-6244-0795
Denis VigliettiParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Luis G HidalgoDepartment of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York.
Lloyd E RatnerDepartment of Surgery, University of California, San Francisco School of Medicine, San Francisco, California.
Serena M BagnascoKidney Transplant Department, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain.
Ibrahim BatalKidney Pancreas Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
Olivier AubertParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Babak J OrandiDepartment of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Federico OppenheimerDepartment of Nephrology and Organ Transplantation, Centre Hospitalier Universitaire Rangueil, Toulouse, Institut National de la Santé et de la Recherche Médicale U1043, Structure Fédérative de Recherche Bio-Médicale de Toulouse, Centre Hospitalier Universitaire Purpan, Toulouse, Université Paul Sabatier, Toulouse, France.
Oriol BestardDepartment of Nephrology, Centre Hospitalier Régional Universitaire de Tours, Tours, France.ORCID 0000-0001-9468-7920
Paolo RigottiPathology Department, Necker Hospital.
Anna V ReisaeterPathology Department, European Georges Pompidou Hospital, and.
Nassim KamarKidney Transplant Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Yvon LebranchuSurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jean-Paul Duong Van HuyenParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Patrick BrunevalParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Denis GlotzParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Christophe LegendreParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Jean-Philippe EmpanaParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Xavier JouvenParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.
Dorry L SegevKidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.ORCID 0000-0002-1924-4801
Robert A MontgomeryDepartment of Surgery, New York University Langone Medical Center, New York, New York; and.
Adriana ZeeviDepartment of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Philip F HalloranDepartment of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York.
Alexandre LoupyParis Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-S970, Paris, France.ORCID 0000-0003-3388-7747
Translational Research in Oncology · FRInserm · FRColumbia University Irving Medical Center · USHospital Clínic de Barcelona · ESThe Metabolomics Innovation Centre · CAUniversity of Padua · ITBellvitge University Hospital · ESCentre Hospitalier Universitaire de Toulouse · FRCentre Hospitalier Universitaire de Tours · FREuropean Hospital · ITJohns Hopkins University · USNYU Langone Health · USSaint Louis University Hospital · USUniversity of Alberta · CAUniversity of California, San Francisco · USUniversity of Pittsburgh Medical Center · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complement-activating anti-HLA donor-specific antibodies (DSAs) are associated with impaired kidney transplant outcome; however, whether these antibodies induce a specific rejection phenotype and influence response to therapy remains undetermined. We prospectively screened 931 kidney recipients for complement-activating DSAs and used histopathology, immunostaining, and allograft gene expression to assess rejection phenotypes. Effector cells were evaluated using
Indexed as
TranscriptomeAdultAgedAllograftsAntibodiesAntibodies, Monoclonal, HumanizedCells, CulturedChemokine CCL4Chemokine CXCL11Complement Inactivator ProteinsComplement System ProteinsFemaleGraft RejectionHLA AntigensHumansImmunoglobulins, IntravenousAntibodiesAntibodies, Monoclonal, HumanizedCCL4 protein, humanChemokine CCL4Chemokine CXCL11Complement Inactivator ProteinsComplement System ProteinsCXCL11 protein, humaneculizumabFCGR3A protein, humanHLA AntigensImmunoglobulins, IntravenousImmunologic FactorsMembrane ProteinsMS4A6A protein, humanMS4A7 protein, humanReceptors, IgGcomplementkidney transplantationrejectiontranscriptional profiling
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