Evidence map›Paper›PMID 29042444›Full record

ArticleThe Journal of biological chemistry2017

Development of novel biosensors to study receptor-mediated activation of the G-protein α subunits G

Hideaki Yano, Davide Provasi, Ning Sheng Cai, Marta Filizola, Sergi Ferré, Jonathan A Javitch

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Characterization of GαiScience · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hideaki YanoNational Institute on Drug Abuse, Baltimore, Maryland 21224. Electronic address: yanoh@nih.gov.
Davide ProvasiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Ning Sheng CaiNational Institute on Drug Abuse, Baltimore, Maryland 21224.
Marta FilizolaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Sergi FerréNational Institute on Drug Abuse, Baltimore, Maryland 21224.
Jonathan A JavitchDepartments of Psychiatry and Pharmacology, College of Physicians & Surgeons, Columbia University, New York, New York 10032; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032. Electronic address: jaj2@columbia.edu.

Funding

Neurotransmitter Receptor Heteromers in the Striatal Spine ModuleZIADA000493 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI FERRE, SERGI · 2009 to 2025
$35.6M
Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
Molecular Determinants for the Action of PsychostimulantsK05DA022413 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2007 to 2016
$1.3M
Structural Aspects of Oligomerization in the Function of GPCRsK02DA026434 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FILIZOLA, MARTA · 2009 to 2018
$1.2M
NIDA NIH HHS K02 DA026434NIDA NIH HHS K05 DA022413NIH HHS S10 OD018522NIMH NIH HHS R01 MH054137
6 · The paper itself

Abstract

Gα

Indexed as

Adenylyl CyclasesAnimalsBioluminescence Resonance Energy Transfer TechniquesBiosensing TechniquesGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, GsHumansLigandsProtein ConformationReceptor, Adenosine A2AReceptors, Dopamine D1Signal TransductionAdenylyl CyclasesGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, GsLigandsolfactory G protein subunit alpha olfReceptor, Adenosine A2AReceptors, Dopamine D1bioluminescence resonance energy transfer (BRET)dopamine receptorG proteinG-protein–coupled receptor (GPCR)pharmacology

Identifiers

PMID29042444
PMCPMC5723988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.