Evidence map›Paper›PMID 29042436›Full record

ArticleThe Journal of biological chemistry2017

Wilms tumor protein-dependent transcription of VEGF receptor 2 and hypoxia regulate expression of the testis-promoting gene

Karin M Kirschner, Lina K Sciesielski, Katharina Krueger, Holger Scholz

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Every Beat You Take-The Wilms' Tumor Suppressor WT1 and the Heart.International journal of molecular sciences · 2021
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Karin M KirschnerInstitut für Vegetative Physiologie, 10117 Berlin, Germany.
Lina K SciesielskiKlinik für Neonatologie, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Katharina KruegerInstitut für Vegetative Physiologie, 10117 Berlin, Germany.
Holger ScholzInstitut für Vegetative Physiologie, 10117 Berlin, Germany. Electronic address: holger.scholz@charite.de.
Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wilms tumor protein 1 (WT1) has been implicated in the control of several genes in sexual development, but its function in gonad formation is still unclear. Here, we report that WT1 stimulates expression of

Indexed as

Transcription, GeneticAnimalsEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalGonadsHypoxiaMaleMiceOvaryPromoter Regions, GeneticRepressor ProteinsRNA, MessengerSOX9 Transcription FactorTestisVascular Endothelial Growth Factor Receptor-2Kdr protein, mouseRepressor ProteinsRNA, MessengerSox9 protein, mouseSOX9 Transcription FactorVascular Endothelial Growth Factor Receptor-2WT1 protein, mouseWT1 Proteinschromatin immunoprecipitation (ChiP)developmentgene regulationgene silencinggene transcriptionhypoxiaimmunohistochemistryovarytestistranscription factor

Identifiers

PMID29042436
PMCPMC5724013
OpenAlexW2766444192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.