ArticleJournal of the American Heart Association2017
Cardiovascular and Metabolic Consequences of Testosterone Supplements in Young and Old Male Spontaneously Hypertensive Rats: Implications for Testosterone Supplements in Men.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Aging-related severe hypertension causes prostatic gland atrophy and testicular injury in rats.Scientific reports · 2026Article
- Sex Hormone Androgen Elevates Blood Pressure Through Gut Microbiota-TMAO Pathway.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Mechanism of salidroside promoting testosterone secretion induced by HFrontiers in chemistry · 2025Article
- Effect of Pituitary-Target Gland Axis on RAAS in the Context of COVID-19.International journal of medical sciences · 2025Review
- Chronic intermittent hypoxia-induced hypertension: the impact of sex hormones.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Review
- ProbioticsmSystems · 2023Article
- The role of sex and gender in hypertension.Journal of human hypertension · 2023Review
- Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases.Frontiers in cardiovascular medicine · 2023Review
- Sex Differences in the Prevalence, Outcomes and Management of Hypertension.Current hypertension reports · 2022Review
- Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging.Biomolecules · 2022Review
- Sex steroids receptors, hypertension, and vascular ageing.Journal of human hypertension · 2022Review
- Testosterone attenuates hypoxia-induced hypertension by affecting NRF1-mediated transcriptional regulation of ET-1 and ACE.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Effects of the oral testosterone undecanoate Kyzatrex™ on ambulatory blood pressure in hypogonadal men.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Protective effects of ginseng stem-leaf saponins on D-galactose-induced reproductive injury in male mice.Aging · 2021Article
- Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients.Therapeutic advances in endocrinology and metabolism · 2020Review
- Study on the Antihypertensive Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Testosterone plays a permissive role in angiotensin II-induced hypertension and cardiac hypertrophy in male rats.Biology of reproduction · 2019Article
- A new approach to study the sex differences in adipose tissue.Journal of biomedical science · 2018Review
- DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats.Current aging science · 2018Article
- Cardiovascular and Metabolic Consequences of Testosterone Supplements in Young and Old Male Spontaneously Hypertensive Rats: Implications for Testosterone Supplements in Men.Journal of the American Heart Association · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe safety of testosterone supplements in men remains unclear. In the present study, we tested the hypothesis that in young and old male spontaneously hypertensive rats (SHR), long-term testosterone supplements increase blood pressure and that the mechanism is mediated in part by activation of the renin-angiotensin system. METHODS AND
resultsIn untreated males, serum testosterone exhibited a sustained decrease after 5 months of age, reaching a nadir by 18 to 22 months of age. The reductions in serum testosterone were accompanied by an increase in body weight until very old age (18 months). Testosterone supplements were given for 6 weeks to young (12 weeks-YMSHR) and old (21-22 months-OMSHR) male SHR that increased serum testosterone by 2-fold in young males and by 4-fold in old males. Testosterone supplements decreased body weight, fat mass, lean mass, and plasma leptin, and increased plasma estradiol in YMSHR but had no effect in OMSHR. Mean arterial pressure (MAP) was significantly higher in OMSHR than in YMSHR and testosterone supplements decreased MAP in OMSHR, but significantly increased MAP in YMSHR. Enalapril, the angiotensin-converting enzyme inhibitor, reduced MAP in both control and testosterone-supplemented YMSHR, but had a greater effect on MAP in testosterone-treated rats, suggesting the mechanism responsible for the increase in MAP in YMSHR is mediated at least in part by activation of the renin-angiotensin system.
conclusionsTaken together with previous studies, these data suggest that testosterone supplements may have differential effects on men depending on age, cardiovascular and metabolic status, and dose and whether given long-term or short-term.
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