ArticleBMJ open2017
Potentially inappropriate prescribing and its association with health outcomes in middle-aged people: a prospective cohort study in Ireland.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Observational
- Drug class duplication patterns among South African middle-aged adults: findings from a medicine claims database.International journal of clinical pharmacy · 2026Article
- Potentially inappropriate prescribing in middle-aged adults: a significant problem with a lack of action and evidence to address it.BJGP open · 2025Article
- Contribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study.Journal of general internal medicine · 2024Observational
- Article
- The patterns and implications of potentially suboptimal medicine regimens among older adults: a narrative review.Therapeutic advances in drug safety · 2022Review
- Factors Associated with Medication Non-Adherence among Patients with Multimorbidity and Polypharmacy Admitted to an Intermediate Care Center.International journal of environmental research and public health · 2021Article
- Prevalence and predictors of potentially inappropriate prescribing in middle-aged adults: a repeated cross-sectional study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Article
- Trends in polypharmacy and potentially inappropriate medication (PIM) in older and middle-aged people treated for diabetes.British journal of clinical pharmacology · 2021Article
- Impact of drug burden index on adverse health outcomes in Irish community-dwelling older people: a cohort study.BMC geriatrics · 2019Article
- The associations of geriatric syndromes and other patient characteristics with the current and future use of potentially inappropriate medications in a large cohort study.European journal of clinical pharmacology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the prevalence of potentially inappropriate prescribing (PIP) in a cohort of community-dwelling middle-aged people and assess the relationship between PIP and emergency department (ED) visits, general practitioner (GP) visits and quality of life (QoL).
designProspective cohort study.
settingThe Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort study of ageing.
participantsIndividuals aged 45-64 years recruited to TILDA who were eligible for the means-tested General Medical Services scheme and followed up after 2 years. EXPOSURE: PIP was determined in the 12 months preceding baseline and follow-up TILDA data collection by applying the PRescribing Optimally in Middle-aged People's Treatments (PROMPT) criteria to participants' medication dispensing data. OUTCOME MEASURES: At follow-up, the reported rates of ED and GP visits over 12 months (primary outcome) and the CASP-R12 (Control Autonomy Self-realisation Pleasure) measure of QoL (secondary outcome). ANALYSIS: Multivariate negative binomial (rates) and linear regression (CASP-R12) models controlling for potential confounders.
resultsAt 2-year follow-up (n=808), PIP was detected in 42.9% by the PROMPT criteria. An ED visit was reported by 18.7% and 94.4% visited a GP (median 4 visits, IQR 2-6). Exposure to ≥2 PROMPT criteria was associated with higher rates of healthcare utilisation and lower QoL in unadjusted regression. However, in multivariate analysis, the associations between PIP and rates of ED visits (adjusted incidence rate ratio (IRR) 0.92, 95% CI 0.53 to 1.58), and GP visits (IRR 1.06, 95% CI 0.87 to 1.28), and CASP-R12 score (adjusted β coefficient 0.35, 95% CI -0.93 to 1.64) were not statistically significant. Numbers of medicines and comorbidities were associated with higher healthcare utilisation.
conclusionsAlthough PIP was prevalent in this study population, there was no evidence of a relationship with ED and GP visits and QoL. Further research should evaluate whether the PROMPT criteria are related to these and other adverse outcomes in the general middle-aged population.
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