Evidence map›Paper›PMID 29042286›Full record

ArticleCellular signalling2018

Protein kinase- and lipase inhibitors of inositide metabolism deplete IP

Subu Surendran Rajasekaran, Christopher Illies, Stephen B Shears, Huanchen Wang, Thais S Ayala, Joilson O Martins, Elisabetta Daré, Per-Olof Berggren, Christopher J Barker

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The inositol pyrophosphate pathway in health and diseases.Biological reviews of the Cambridge Philosophical Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Subu Surendran RajasekaranThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Christopher IlliesThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Stephen B ShearsSignal Transduction Laboratory/Inositol Signaling Group, NIEHS, Building 101, Room F239, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
Huanchen WangSignal Transduction Laboratory/Inositol Signaling Group, NIEHS, Building 101, Room F239, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
Thais S AyalaThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Joilson O MartinsLaboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Elisabetta DaréThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Per-Olof BerggrenThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden. Electronic address: per-olof.berggren@ki.se.
Christopher J BarkerThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden. Electronic address: chris.barker@ki.se.
Karolinska Institutet · SENational Institute of Environmental Health Sciences · USUniversidade de São Paulo · BR

Funding

Inositol SignallingZIAES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 2009 to 2023
$31.3M
REGULATION OF INOSITOL LIPID SIGNALLING MECHANISMSZ01ES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 1990 to 2008
$4.3M
Intramural NIH HHS Z01 ES080046
6 · The paper itself

Abstract

Inositol pyrophosphates have emerged as important regulators of many critical cellular processes from vesicle trafficking and cytoskeletal rearrangement to telomere length regulation and apoptosis. We have previously demonstrated that 5-di-phosphoinositol pentakisphosphate, IP

Indexed as

Adenosine DiphosphateAdenosine TriphosphateAndrostadienesAnimalsArsenicalsCell LineChromonesCricetulusEnzyme InhibitorsEstrenesGene ExpressionHumansInositol PhosphatesInsulinInsulin-Secreting CellsInsulin Secretion1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione1-diphosphoinositol pentakisphosphate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one4,5,6,7-tetrabromobenzotriazoleAdenosine DiphosphateAdenosine TriphosphateAndrostadienesArsenicalsChromonesEnzyme InhibitorsEstrenesInositol PhosphatesInsulinIP6K1 protein, humanMorpholinesoxophenylarsinePhosphotransferases (Phosphate Group Acceptor)PyrrolidinonesReceptor, InsulinRecombinant ProteinsSuccinimidesTriazolesWortmanninATP/ADPDi-phosphoinositol pentakisphosphateInositol hexakisphosphate kinaseInositol pyrophosphatePancreatic β-cellPharmacological inhibitors

Identifiers

PMID29042286
PMCPMC5765549
OpenAlexW2766505210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.