Evidence map›Paper›PMID 29041963›Full record

ArticleArthritis research & therapy2017

Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study.

Jasvinder A Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang, Jeffrey R Curtis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. A glance into the future of gout.Therapeutic advances in musculoskeletal disease · 2022
    Review
  15. Hyperuricemia, Gout, and the Brain-an Update.Current rheumatology reports · 2021
    Review
  16. What Has Dual Energy CT Taught Us About Gout?Current rheumatology reports · 2021
    Review
  17. Article
  18. Urate Crystals; Beyond Joints.Frontiers in medicine · 2021
    Review
  19. Review
  20. Multiarticular Deforming and Erosive Tophaceous Gout With Severe Comorbidities.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jasvinder A SinghMedicine Service, VA Medical Center, 700 South 19th Street, Birmingham, AL, 35233, USA. jasvinder.md@gmail.com.
Rekha RamachandaranMedicine Service, VA Medical Center, 700 South 19th Street, Birmingham, AL, 35233, USA.
Shaohua YuDepartment of Medicine, University of Alabama at Birmingham School of Medicine, 510 20th Street South, Faculty Office Tower 805B, Birmingham, AL, 35294-0022, USA.
Shuo YangDepartment of Medicine, University of Alabama at Birmingham School of Medicine, 510 20th Street South, Faculty Office Tower 805B, Birmingham, AL, 35294-0022, USA.
Fenglong XieDepartment of Medicine, University of Alabama at Birmingham School of Medicine, 510 20th Street South, Faculty Office Tower 805B, Birmingham, AL, 35294-0022, USA.
Huifeng YunDivision of Epidemiology, University of Alabama at Birmingham School of Public Health, 1720 Second Avenue South, Birmingham, AL, 35294-0022, USA.
Jie ZhangDivision of Epidemiology, University of Alabama at Birmingham School of Public Health, 1720 Second Avenue South, Birmingham, AL, 35294-0022, USA.
Jeffrey R CurtisDepartment of Medicine, University of Alabama at Birmingham School of Medicine, 510 20th Street South, Faculty Office Tower 805B, Birmingham, AL, 35294-0022, USA.
University of Alabama at Birmingham · USBirmingham VA Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess whether gout is as strong a risk factor as diabetes mellitus (DM) for incident MI and incident stroke.

methodsIn this retrospective study, we used U.S. claims data from 2007 to 2010 that included a mix of private and public health plans. Four mutually exclusive cohorts were identified: (1) DM only, (2) gout only, (3) gout and DM, and (4) neither gout nor DM. Outcomes were acute MI or stroke with hospitalization. We compared the age- and sex-specific rates of incident MI and stroke across the four cohorts and assessed multivariable-adjusted HRs.

resultsIn this study, 232,592 patients had DM, 71,755 had gout, 23,261 had both, and 1,010,893 had neither. The incidence of acute MI was lowest in patients with neither gout nor DM, followed by patients with gout alone, DM alone, and both. Among men >80 years of age, the respective rates/1000 person-years were 14.6, 25.4, 27.7, and 37.4. Similar trends were noted for stroke and in women. Compared with DM only, gout was associated with a significantly lower adjusted HR of incident MI (HR 0.81, 95% CI 0.76-0.87) but a similar risk of stroke (HR 1.02, 95% CI 0.95-1.10). Compared with patients with DM only, patients with both gout and DM had higher HRs for incident MI and stroke (respectively, HR 1.35, 95% CI 1.25-1.47; HR 1.42, 95% CI 1.29-1.56).

conclusionsGout is a risk equivalent to DM for incident stroke but not for incident MI. Having both gout and DM confers incremental risk compared with DM alone for both incident MI and stroke.

Indexed as

AdultAgedAged, 80 and overCohort StudiesDatabases, FactualDiabetes ComplicationsDiabetes MellitusFemaleGoutHumansIncidenceMaleMiddle AgedMyocardial InfarctionRetrospective StudiesRisk FactorsDiabetesGoutMyocardial infarctionRisk equivalentStroke

Identifiers

PMID29041963
PMCPMC5646136
OpenAlexW2765393911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.