Evidence map›Paper›PMID 29041912›Full record

ArticleBMC cardiovascular disorders2017

Quality of life questionnaire predicts poor exercise capacity only in HFpEF and not in HFrEF.

Artan Ahmeti, Michael Y Henein, Pranvera Ibrahimi, Shpend Elezi, Edmond Haliti, Afrim Poniku, Arlind Batalli, Gani Bajraktari

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Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Artan AhmetiClinic of Cardiology, University Clinical Centre of Kosova, Rrethi i Spitalit, P.N, 10000, Prishtina, Kosovo.
Michael Y HeneinDepartment of Public Health and Clinical Medicine, Umeå University and Heart Centre, Umeå, Sweden.
Pranvera IbrahimiClinic of Cardiology, University Clinical Centre of Kosova, Rrethi i Spitalit, P.N, 10000, Prishtina, Kosovo.
Shpend EleziMedical Faculty, University of Prishtina, Prishtina, Kosovo.
Edmond HalitiClinic of Cardiology, University Clinical Centre of Kosova, Rrethi i Spitalit, P.N, 10000, Prishtina, Kosovo.
Afrim PonikuClinic of Cardiology, University Clinical Centre of Kosova, Rrethi i Spitalit, P.N, 10000, Prishtina, Kosovo.
Arlind BatalliClinic of Cardiology, University Clinical Centre of Kosova, Rrethi i Spitalit, P.N, 10000, Prishtina, Kosovo.
Gani BajraktariClinic of Cardiology, University Clinical Centre of Kosova, Rrethi i Spitalit, P.N, 10000, Prishtina, Kosovo. gani.bajraktari@uni-pr.edu.ORCID http://orcid.org/0000-0003-0410-968X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the most widely used measure of quality of life (QoL) in HF patients. This prospective study aimed to assess the relationship between QoL and exercise capacity in HF patients.

methodsThe study subjects were 118 consecutive patients with chronic HF (62 ± 10 years, 57 females, in NYHA I-III). Patients answered a MLHFQ questionnaire in the same day of complete clinical, biochemical and echocardiographic assessment. They also underwent a 5 min walk test (6-MWT), in the same day, which grouped them into; Group I: ≤ 300 m and Group II: >300 m. In addition, left ventricular (LV) ejection fraction (EF), divided them into: Group A, with preserved EF (HFpEF) and Group B with reduced EF (HFrEF).

resultsThe mean MLHFQ total scale score was 48 (±17). The total scale, and the physical and emotional functional MLHFQ scores did not differ between HFpEF and HFpEF. Group I patients were older (p = 0.003), had higher NYHA functional class (p = 0.002), faster baseline heart rate (p = 0.006), higher prevalence of smoking (p = 0.015), higher global, physical and emotional MLHFQ scores (p < 0.001, for all), larger left atrial (LA) diameter (p = 0.001), shorter LV filling time (p = 0.027), higher E/e' ratio (0.02), shorter isovolumic relaxation time (p = 0.028), lower septal a' (p = 0.019) and s' (p = 0.023), compared to Group II. Independent predictors of 6-MWT distance for the group as a whole were increased MLHFQ total score (p = 0.005), older age (p = 0.035), and diabetes (p = 0.045), in HFpEF were total MLHFQ (p = 0.007) and diabetes (p = 0.045) but in HFrEF were only LA enlargement (p = 0.005) and age (p = 0.013. A total MLHFQ score of 48.5 had a sensitivity of 67% and specificity of 63% (AUC on ROC analysis of 72%) for limited exercise performance in HF patients.

conclusionsQuality of life, assessment by MLHFQ, is the best correlate of exercise capacity measured by 6-MWT, particularly in HFpEF patients. Despite worse ejection fraction in HFrEF, signs of raised LA pressure independently determine exercise capacity in these patients.

Indexed as

Surveys and QuestionnairesAgedExercise ToleranceFemaleHeart FailureHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesQuality of LifeStroke Volume6 min walk testEchocardiographyExercise capacityHeart failureQuality of lifeThe Minnesota Living with Heart Failure Questionnaire

Identifiers

PMID29041912
PMCPMC5646144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.