ArticleSchizophrenia bulletin2018
Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- Brain network controllability in genetic risk, childhood abuse, and adult anxiety.European journal of psychotraumatology · 2025Article
- Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients.Brain imaging and behavior · 2025Article
- Genetic risk for schizophrenia and brain activation during the Penn Conditional Exclusion Test: A multiplex extended pedigree study.Journal of psychopathology and clinical science · 2025Article
- A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex.Science (New York, N.Y.) · 2024Article
- Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects.Frontiers in neurology · 2024Article
- Changes in patterns of age-related network connectivity are associated with risk for schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex.bioRxiv : the preprint server for biology · 2023Article
- Article
- Functional connectome-wide associations of schizophrenia polygenic risk.Molecular psychiatry · 2021Article
- The association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences.Translational psychiatry · 2021Article
- Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function.JAMA psychiatry · 2020Article
- Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems.NPJ schizophrenia · 2018Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Recent work has begun to shed light on the neural correlates and possible mechanisms of polygenic risk for schizophrenia. Here, we map a schizophrenia polygenic risk profile score (PRS) based on genome-wide association study significant loci onto variability in the activity and functional connectivity of a frontoparietal network supporting the manipulation versus maintenance of information during a numerical working memory (WM) task in healthy young adults (n = 99, mean age = 19.8). Our analyses revealed that higher PRS was associated with hypoactivity of the dorsolateral prefrontal cortex (dlPFC) during the manipulation but not maintenance of information in WM (r2 = .0576, P = .018). Post hoc analyses revealed that PRS-modulated dlPFC hypoactivity correlated with faster reaction times during WM manipulation (r2 = .0967, P = .002), and faster processing speed (r2 = .0967, P = .003) on a separate behavioral task. These PRS-associated patterns recapitulate dlPFC hypoactivity observed in patients with schizophrenia during central executive manipulation of information in WM on this task.
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