Evidence map›Paper›PMID 29040701›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2018

Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort.

Jonas Björk, Anders Grubb, Vilmundur Gudnason, Olafur S Indridason, Andrew S Levey, Runolfur Palsson, Ulf Nyman

Open access · bronzeAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  20. Estimated GFR: time for a critical appraisal.Nature reviews. Nephrology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Jonas BjörkClinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden.
Anders GrubbDepartment of Clinical Chemistry, Skåne University Hospital, Lund University, Lund, Sweden.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Olafur S IndridasonDivision of Nephrology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
Andrew S LeveyDivision of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.
Runolfur PalssonDivision of Nephrology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
Ulf NymanDepartment of Translational Medicine, Division of Medical Radiology, Lund University, Malmö, Sweden.
Lund University · SENational University Hospital of Iceland · ISIcelandic Heart Association · ISSkåne University Hospital · SETufts Medical Center · US

Funding

Kidney Function, Aortic Stiffness and AgingR01DK082447 · NIDDK · TUFTS MEDICAL CENTER · PI LEVEY, ANDREW S · 2010 to 2014
$2.4M
NIDDK NIH HHS R01 DK082447
6 · The paper itself

Abstract

Background: Validation studies comparing glomerular filtration rate (GFR) equations based on standardized creatinine and cystatin C assays in the elderly are needed. The Icelandic Age, Gene/Environment Susceptibility-Kidney cohort was used to compare two pairs of recently developed GFR equations, the revised Lund-Malmö creatinine equation (LMRCr) and the arithmetic mean of the LMRCr and Caucasian, Asian, Paediatric and Adult cystatin C equations (MEANLMR+CAPA), as well as the Full Age Spectrum creatinine equation (FASCr) and its combination with cystatin C (FASCr+Cys), with the corresponding pair of Chronic Kidney Disease Epidemiology Collaboration equations (CKD-EPICr and CKD-EPICr+Cys). Methods: A total of 805 individuals, 74-93 years of age, underwent measurement of GFR (mGFR) using plasma clearance of iohexol. Four metrics were used to compare the performance of the GFR equations: bias, precision, accuracy [including the percentage of participants with estimated GFR (eGFR) within 30% of mGFR (P30)] and the ability to detect mGFR <60 mL/min/1.73 m2. Results: All equations had a P30 >90%. LMRCr and FASCr yielded significantly higher precision and P30 than CKD-EPICr, while bias was significantly worse. LMRCr, FASCr and CKD-EPICr showed similar ability to detect mGFR <60 mL/min/1.73 m2 based on the area under the receiver operating characteristic curves. MEANLMR+CAPA, FASCr+Cys and CKD-EPICr+Cys all exhibited consistent improvements compared with the corresponding creatinine-based equations. Conclusion: None of the creatinine-based equations was clearly superior overall in this community-dwelling elderly cohort. The addition of cystatin C improved all of the creatinine-based equations.

Indexed as

Genetic Predisposition to DiseaseAdultAgedAged, 80 and overCreatinineCystatin CFemaleGlomerular Filtration RateHumansIcelandKidney Function TestsMaleMiddle AgedProspective StudiesRenal Insufficiency, ChronicROC CurveCreatinineCystatin C

Identifiers

PMID29040701
PMCPMC6070032
OpenAlexW2763359546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.