Evidence map›Paper›PMID 29040685›Full record

ArticleInternational journal of epidemiology2017

A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA.

Nan Li, Jessica L Petrick, Susan E Steck, Patrick T Bradshaw, Kathleen M McClain, Nicole M Niehoff, Lawrence S Engel, Nicholas J Shaheen, Harvey A Risch, Thomas L Vaughan and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Composite health behaviour classifier as the basis for targeted interventions and global comparisons in men's health.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2019
    Article
  18. Article
  19. Update on the management of Barrett's esophagus in Austria.European surgery : ACA : Acta chirurgica Austriaca · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nan LiDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC, USA.
Jessica L PetrickDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Susan E SteckDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
Patrick T BradshawDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Kathleen M McClainDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC, USA.
Nicole M NiehoffDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC, USA.
Lawrence S EngelDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC, USA.
Nicholas J ShaheenDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC, USA.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Newhaven, CT, USA.
Thomas L VaughanProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Anna H WuKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marilie D GammonDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC, USA.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
Whole Exome Approaches for Esophageal Adenocarcinoma Susceptibility GenesU54CA163060 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI CHAK, AMITABH, GUDA, KISHORE · 2011 to 2022
$14.0M
ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROLK05CA124911 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 2007 to 2016
$1.6M
EPIDEMIOLOGIC STUDY OF ESOPHAGEAL/GASTRIC ADENOCARCINOMAU01CA057923 · NCI · YALE UNIVERSITY · PI RISCH, HARVEY A · 1992 to 1995
–
EPIDEMIOLOGIC STUDY OF ADENOCARCINOMAS OF THE ESOPHAGUSU01CA057949 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 1992 to 1995
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ADENOCARCINOMAS OF THE ESOPHAGUS AND GASTRIC CARDIAU01CA057983 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GAMMON, MARILIE D · 1992 to 1995
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NCI NIH HHS K05 CA124911NCI NIH HHS U01 CA057923NCI NIH HHS U01 CA057949NCI NIH HHS U01 CA057983NCI NIH HHS U54 CA163060NIEHS NIH HHS P30 ES007048NIEHS NIH HHS T32 ES007018
6 · The paper itself

Abstract

Background: During the past 40 years, esophageal/gastric cardia adenocarcinoma (EA/GCA) incidence increased in Westernized countries, but survival remained low. A parallel increase in sugar intake, which may facilitate carcinogenesis by promoting hyperglycaemia, led us to examine sugar/carbohydrate intake in association with EA/GCA incidence and survival. Methods: We pooled 500 EA cases, 529 GCA cases and 2027 controls from two US population-based case-control studies with cases followed for vital status. Dietary intake, assessed by study-specific food frequency questionnaires, was harmonized and pooled to estimate 12 measures of sugar/carbohydrate intake. Multivariable-adjusted odds ratios (ORs) and hazard ratios [95% confidence intervals (CIs)] were calculated using multinomial logistic regression and Cox proportional hazards regression, respectively. Results: EA incidence was increased by 51-58% in association with sucrose (ORQ5vs.Q1 = 1.51, 95% CI = 1.01-2.27), sweetened desserts/beverages (ORQ5vs.Q1 = 1.55, 95% CI = 1.06-2.27) and the dietary glycaemic index (ORQ5vs.Q1 = 1.58, 95% CI = 1.13-2.21). Body mass index (BMI) and gastro-esophageal reflux disease (GERD) modified these associations (Pmultiplicative-interaction ≤ 0.05). For associations with sucrose and sweetened desserts/beverages, respectively, the OR was elevated for BMI < 25 (ORQ4-5vs.Q1-3 = 1.79, 95% CI = 1.26-2.56 and ORQ4-5vs.Q1-3 = 1.45, 95% CI = 1.03-2.06), but not BMI ≥ 25 (ORQ4-5vs.Q1-3 = 1.05, 95% CI = 0.76-1.44 and ORQ4-5vs.Q1-3 = 0.85, 95% CI = 0.62-1.16). The EA-glycaemic index association was elevated for BMI ≥ 25 (ORQ4-5vs.Q1-3 = 1.38, 95% CI = 1.03-1.85), but not BMI < 25 (ORQ4-5vs.Q1-3 = 0.88, 95% CI = 0.62-1.24). The sucrose-EA association OR for GERD < weekly was 1.58 (95% CI = 1.16-2.14), but for GERD ≥ weekly was 1.01 (95% CI = 0.70-1.47). Sugar/carbohydrate measures were not associated with GCA incidence or EA/GCA survival. Conclusions: If confirmed, limiting intake of sucrose (e.g. table sugar), sweetened desserts/beverages, and foods that contribute to a high glycaemic index, may be plausible EA risk reduction strategies.

Indexed as

AdenocarcinomaAgedBlood GlucoseBody Mass IndexCase-Control StudiesDietary CarbohydratesDietary SucroseEsophageal NeoplasmsFemaleGastroesophageal RefluxHumansIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisBlood GlucoseDietary CarbohydratesDietary Sucroseesophageal adenocarcinomaglycaemic indexSucrosesweetened desserts/beverages

Identifiers

PMID29040685
PMCPMC5837717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.